Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases
Background: Spinal metastasis pain includes both inflammatory and neuropathic pain, and opioids, which have only a ?-opioid receptor-stimulating effect, are generally less effective in neuropathic pain. However, no previous study has been conducted for the comparisons of the efficacy of opioids in t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mary Ann Liebert
2023-08-01
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| Series: | Palliative Medicine Reports |
| Subjects: | |
| Online Access: | https://www.liebertpub.com/doi/full/10.1089/PMR.2023.0018 |
| _version_ | 1797346089696755712 |
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| author | Miho Takemura Kazuyuki Niki Yoshiaki Okamoto Hiroshi Tamura Tomohiro Kawamura Makie Kohno Yoshinobu Matsuda Kenji Ikeda |
| author_facet | Miho Takemura Kazuyuki Niki Yoshiaki Okamoto Hiroshi Tamura Tomohiro Kawamura Makie Kohno Yoshinobu Matsuda Kenji Ikeda |
| author_sort | Miho Takemura |
| collection | DOAJ |
| description | Background: Spinal metastasis pain includes both inflammatory and neuropathic pain, and opioids, which have only a ?-opioid receptor-stimulating effect, are generally less effective in neuropathic pain. However, no previous study has been conducted for the comparisons of the efficacy of opioids in treating spinal metastasis pain.
Objective: To compare the efficacy of tapentadol and methadone with other opioids for back pain caused by a metastatic spinal tumor.
Design: Retrospective cohort study.
Setting/Subjects: A total of 274 patients were enrolled, who started a tapentadol extended-release tablet, methadone tablet, hydromorphone extended-release tablet, oxycodone extended-release tablet, or transdermal fentanyl patch for cancer pain due to spinal metastasis in Japan from January 1, 2013 to October 31, 2021.
Measurements: The primary endpoint, the difference in the numerical rating scale (NRS) scores before and seven days after each opioid administration, was compared among the five groups.
Results: In patients with numbness, a decrease of the NRS score on day seven compared with before starting each opioid was significantly higher in the tapentadol group than those in the hydromorphone, oxycodone, and fentanyl groups and comparable to that in the methadone group. In patients without numbness, no significant differences were observed in decreases of the NRS scores on day seven among the five groups.
Conclusions: Tapentadol and methadone may be more effective than hydromorphone, oxycodone, and fentanyl for cancer pain due to spinal metastasis with numbness. |
| first_indexed | 2024-03-08T11:26:47Z |
| format | Article |
| id | doaj.art-62266510d97c40f28e1eaacea8b81fbd |
| institution | Directory Open Access Journal |
| issn | 2689-2820 |
| language | English |
| last_indexed | 2024-03-08T11:26:47Z |
| publishDate | 2023-08-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Palliative Medicine Reports |
| spelling | doaj.art-62266510d97c40f28e1eaacea8b81fbd2024-01-26T05:09:40ZengMary Ann LiebertPalliative Medicine Reports2689-28202023-08-014122023010.1089/PMR.2023.0018Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal MetastasesMiho TakemuraKazuyuki NikiYoshiaki OkamotoHiroshi TamuraTomohiro KawamuraMakie KohnoYoshinobu MatsudaKenji IkedaBackground: Spinal metastasis pain includes both inflammatory and neuropathic pain, and opioids, which have only a ?-opioid receptor-stimulating effect, are generally less effective in neuropathic pain. However, no previous study has been conducted for the comparisons of the efficacy of opioids in treating spinal metastasis pain. Objective: To compare the efficacy of tapentadol and methadone with other opioids for back pain caused by a metastatic spinal tumor. Design: Retrospective cohort study. Setting/Subjects: A total of 274 patients were enrolled, who started a tapentadol extended-release tablet, methadone tablet, hydromorphone extended-release tablet, oxycodone extended-release tablet, or transdermal fentanyl patch for cancer pain due to spinal metastasis in Japan from January 1, 2013 to October 31, 2021. Measurements: The primary endpoint, the difference in the numerical rating scale (NRS) scores before and seven days after each opioid administration, was compared among the five groups. Results: In patients with numbness, a decrease of the NRS score on day seven compared with before starting each opioid was significantly higher in the tapentadol group than those in the hydromorphone, oxycodone, and fentanyl groups and comparable to that in the methadone group. In patients without numbness, no significant differences were observed in decreases of the NRS scores on day seven among the five groups. Conclusions: Tapentadol and methadone may be more effective than hydromorphone, oxycodone, and fentanyl for cancer pain due to spinal metastasis with numbness.https://www.liebertpub.com/doi/full/10.1089/PMR.2023.0018bone metastasis paincancer pain managementmethadoneopioidsspinal metastasistapentadol |
| spellingShingle | Miho Takemura Kazuyuki Niki Yoshiaki Okamoto Hiroshi Tamura Tomohiro Kawamura Makie Kohno Yoshinobu Matsuda Kenji Ikeda Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases Palliative Medicine Reports bone metastasis pain cancer pain management methadone opioids spinal metastasis tapentadol |
| title | Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases |
| title_full | Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases |
| title_fullStr | Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases |
| title_full_unstemmed | Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases |
| title_short | Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases |
| title_sort | differences in the analgesic effect of opioids on pain in cancer patients with spinal metastases |
| topic | bone metastasis pain cancer pain management methadone opioids spinal metastasis tapentadol |
| url | https://www.liebertpub.com/doi/full/10.1089/PMR.2023.0018 |
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