Oxidative Stress and Preeclampsia-Associated Prothrombotic State
Preeclampsia (PE) is a common obstetric disease characterized by hypertension, proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health. Although hemostasis is critical for preventing bleeding complications during pregnancy, delivery, and post-partum, PE patients often...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/11/1139 |
| _version_ | 1827702117817647104 |
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| author | Cha Han Pengzhu Huang Meilu Lyu Jingfei Dong |
| author_facet | Cha Han Pengzhu Huang Meilu Lyu Jingfei Dong |
| author_sort | Cha Han |
| collection | DOAJ |
| description | Preeclampsia (PE) is a common obstetric disease characterized by hypertension, proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health. Although hemostasis is critical for preventing bleeding complications during pregnancy, delivery, and post-partum, PE patients often develop a severe prothrombotic state, potentially resulting in life-threatening thrombosis and thromboembolism. The cause of this thrombotic complication is multi-factorial, involving endothelial cells, platelets, adhesive ligands, coagulation, and fibrinolysis. Increasing evidence has shown that hemostatic cells and factors undergo oxidative modifications during the systemic inflammation found in PE patients. However, it is largely unknown how these oxidative modifications of hemostasis contribute to development of the PE-associated prothrombotic state. This knowledge gap has significantly hindered the development of predictive markers, preventive measures, and therapeutic agents to protect women during pregnancy. Here we summarize reports in the literature regarding the effects of oxidative stress and antioxidants on systemic hemostasis, with emphasis on the condition of PE. |
| first_indexed | 2024-03-10T14:47:43Z |
| format | Article |
| id | doaj.art-6226b2bac9bf45c68ba461042ed0fff5 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T14:47:43Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-6226b2bac9bf45c68ba461042ed0fff52023-11-20T21:12:13ZengMDPI AGAntioxidants2076-39212020-11-01911113910.3390/antiox9111139Oxidative Stress and Preeclampsia-Associated Prothrombotic StateCha Han0Pengzhu Huang1Meilu Lyu2Jingfei Dong3Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaBloodworks Research Institute, Seattle, WA 98102, USAPreeclampsia (PE) is a common obstetric disease characterized by hypertension, proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health. Although hemostasis is critical for preventing bleeding complications during pregnancy, delivery, and post-partum, PE patients often develop a severe prothrombotic state, potentially resulting in life-threatening thrombosis and thromboembolism. The cause of this thrombotic complication is multi-factorial, involving endothelial cells, platelets, adhesive ligands, coagulation, and fibrinolysis. Increasing evidence has shown that hemostatic cells and factors undergo oxidative modifications during the systemic inflammation found in PE patients. However, it is largely unknown how these oxidative modifications of hemostasis contribute to development of the PE-associated prothrombotic state. This knowledge gap has significantly hindered the development of predictive markers, preventive measures, and therapeutic agents to protect women during pregnancy. Here we summarize reports in the literature regarding the effects of oxidative stress and antioxidants on systemic hemostasis, with emphasis on the condition of PE.https://www.mdpi.com/2076-3921/9/11/1139preeclampsiahemostasisplateletscoagulationoxidative stress |
| spellingShingle | Cha Han Pengzhu Huang Meilu Lyu Jingfei Dong Oxidative Stress and Preeclampsia-Associated Prothrombotic State Antioxidants preeclampsia hemostasis platelets coagulation oxidative stress |
| title | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
| title_full | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
| title_fullStr | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
| title_full_unstemmed | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
| title_short | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
| title_sort | oxidative stress and preeclampsia associated prothrombotic state |
| topic | preeclampsia hemostasis platelets coagulation oxidative stress |
| url | https://www.mdpi.com/2076-3921/9/11/1139 |
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