Understanding Transcriptomic and Serological Differences between Forced Molting and Natural Molting in Laying Hens
Molting is natural adaptation to climate change in all birds, including chickens. Forced molting (FM) can rejuvenate and reactivate the reproductive potential of aged hens, but the effect of natural molting (NM) on older chickens is not clear. To explore why FM has a dramatically different effect on...
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MDPI AG
2021-12-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/1/89 |
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| author | Tongyu Zhang Zhonghua Ning Yu Chen Junhui Wen Yaxiong Jia Liang Wang Xueze Lv Weifang Yang Changqing Qu Haiying Li Huie Wang Lujiang Qu |
| author_facet | Tongyu Zhang Zhonghua Ning Yu Chen Junhui Wen Yaxiong Jia Liang Wang Xueze Lv Weifang Yang Changqing Qu Haiying Li Huie Wang Lujiang Qu |
| author_sort | Tongyu Zhang |
| collection | DOAJ |
| description | Molting is natural adaptation to climate change in all birds, including chickens. Forced molting (FM) can rejuvenate and reactivate the reproductive potential of aged hens, but the effect of natural molting (NM) on older chickens is not clear. To explore why FM has a dramatically different effect on chickens compared with NM, the transcriptome analyses of the hypothalamus and ovary in forced molted and natural molted hens at two periods with feathers fallen and regrown were performed. Additionally, each experimental chicken was tested for serological indices. The results of serological indices showed that growth hormone, thyroid stimulating hormone, and thyroxine levels were significantly higher (<i>p</i> < 0.05) in forced molted hens than in natural molted hens, and calcitonin concentrations were lower in the forced molted than in the natural molted hens. Furthermore, the transcriptomic analysis revealed a large number of genes related to disease resistance and anti-aging in the two different FM and NM periods. These regulatory genes and serological indices promote reproductive function during FM. This study systematically revealed the transcriptomic and serological differences between FM and NM, which could broaden our understanding of aging, rejuvenation, egg production, and welfare issues related to FM in chickens. |
| first_indexed | 2024-03-10T01:24:48Z |
| format | Article |
| id | doaj.art-6227f1be912042c0be4482fcf9e06126 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T01:24:48Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-6227f1be912042c0be4482fcf9e061262023-11-23T13:52:08ZengMDPI AGGenes2073-44252021-12-011318910.3390/genes13010089Understanding Transcriptomic and Serological Differences between Forced Molting and Natural Molting in Laying HensTongyu Zhang0Zhonghua Ning1Yu Chen2Junhui Wen3Yaxiong Jia4Liang Wang5Xueze Lv6Weifang Yang7Changqing Qu8Haiying Li9Huie Wang10Lujiang Qu11State Key Laboratory of Animal Nutrition, Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaBeijing Animal Husbandry and Veterinary Station, Beijing 100107, ChinaState Key Laboratory of Animal Nutrition, Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaBeijing Animal Husbandry and Veterinary Station, Beijing 100107, ChinaBeijing Animal Husbandry and Veterinary Station, Beijing 100107, ChinaBeijing Animal Husbandry and Veterinary Station, Beijing 100107, ChinaEngineering Technology Research Center of Anti-Aging Chinese Herbal Medicine of Anhui Province, Fuyang Normal University, Fuyang 236037, ChinaCollege of Animal Science, Xinjiang Agricultural University, Urumqi 830052, ChinaCollege of Animal Science, Tarim University, Alar 843300, ChinaState Key Laboratory of Animal Nutrition, Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaMolting is natural adaptation to climate change in all birds, including chickens. Forced molting (FM) can rejuvenate and reactivate the reproductive potential of aged hens, but the effect of natural molting (NM) on older chickens is not clear. To explore why FM has a dramatically different effect on chickens compared with NM, the transcriptome analyses of the hypothalamus and ovary in forced molted and natural molted hens at two periods with feathers fallen and regrown were performed. Additionally, each experimental chicken was tested for serological indices. The results of serological indices showed that growth hormone, thyroid stimulating hormone, and thyroxine levels were significantly higher (<i>p</i> < 0.05) in forced molted hens than in natural molted hens, and calcitonin concentrations were lower in the forced molted than in the natural molted hens. Furthermore, the transcriptomic analysis revealed a large number of genes related to disease resistance and anti-aging in the two different FM and NM periods. These regulatory genes and serological indices promote reproductive function during FM. This study systematically revealed the transcriptomic and serological differences between FM and NM, which could broaden our understanding of aging, rejuvenation, egg production, and welfare issues related to FM in chickens.https://www.mdpi.com/2073-4425/13/1/89forced moltingnatural moltingserological indicestranscriptomic analysischickens |
| spellingShingle | Tongyu Zhang Zhonghua Ning Yu Chen Junhui Wen Yaxiong Jia Liang Wang Xueze Lv Weifang Yang Changqing Qu Haiying Li Huie Wang Lujiang Qu Understanding Transcriptomic and Serological Differences between Forced Molting and Natural Molting in Laying Hens Genes forced molting natural molting serological indices transcriptomic analysis chickens |
| title | Understanding Transcriptomic and Serological Differences between Forced Molting and Natural Molting in Laying Hens |
| title_full | Understanding Transcriptomic and Serological Differences between Forced Molting and Natural Molting in Laying Hens |
| title_fullStr | Understanding Transcriptomic and Serological Differences between Forced Molting and Natural Molting in Laying Hens |
| title_full_unstemmed | Understanding Transcriptomic and Serological Differences between Forced Molting and Natural Molting in Laying Hens |
| title_short | Understanding Transcriptomic and Serological Differences between Forced Molting and Natural Molting in Laying Hens |
| title_sort | understanding transcriptomic and serological differences between forced molting and natural molting in laying hens |
| topic | forced molting natural molting serological indices transcriptomic analysis chickens |
| url | https://www.mdpi.com/2073-4425/13/1/89 |
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