Mesenchymal Stem Cells for Perianal Crohn’s Disease
Perianal fistulizing Crohn’s disease (PFCD) is associated with significant morbidity and might negatively impact the quality of life of CD patients. In the last two decades, the management of PFCD has evolved in terms of the multidisciplinary approach involving gastroenterologists and colo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/7/764 |
| _version_ | 1827887039981289472 |
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| author | Michele Carvello Amy Lightner Takayuki Yamamoto Paulo Gustavo Kotze Antonino Spinelli |
| author_facet | Michele Carvello Amy Lightner Takayuki Yamamoto Paulo Gustavo Kotze Antonino Spinelli |
| author_sort | Michele Carvello |
| collection | DOAJ |
| description | Perianal fistulizing Crohn’s disease (PFCD) is associated with significant morbidity and might negatively impact the quality of life of CD patients. In the last two decades, the management of PFCD has evolved in terms of the multidisciplinary approach involving gastroenterologists and colorectal surgeons. However, the highest fistula healing rates, even combining surgical and anti-TNF agents, reaches 50% of treated patients. More recently, the administration of mesenchymal stem cells (MSCs) have shown notable promising results in the treatment of PFCD. The aim of this review is to describe the rationale and the possible mechanism of action of MSC application for PFCD and the most recent results of randomized clinical trials. Furthermore, the unmet needs of the current administration process and the expected next steps to improve the outcomes will be addressed. |
| first_indexed | 2024-03-12T20:12:37Z |
| format | Article |
| id | doaj.art-6228bbdfc01048c4984c9ae2f766eb20 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T20:12:37Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6228bbdfc01048c4984c9ae2f766eb202023-08-02T01:34:32ZengMDPI AGCells2073-44092019-07-018776410.3390/cells8070764cells8070764Mesenchymal Stem Cells for Perianal Crohn’s DiseaseMichele Carvello0Amy Lightner1Takayuki Yamamoto2Paulo Gustavo Kotze3Antonino Spinelli4Colon and Rectal Surgery Unit, Humanitas Clinical and Research Center, 20089 Rozzano, ItalyDepartment of Colon and Rectal Surgery, Cleveland Clinic, Cleveland, OH 44195, USAInflammatory Bowel Disease Centre, Yokkaichi Hazu Medical Centre, Yokkaichi, Mie 510-0016, JapanColorectal Surgery Unit, Cajuru University Hospital, Catholic University of Paraná, Curitiba 80215-901, BrazilColon and Rectal Surgery Unit, Humanitas Clinical and Research Center, 20089 Rozzano, ItalyPerianal fistulizing Crohn’s disease (PFCD) is associated with significant morbidity and might negatively impact the quality of life of CD patients. In the last two decades, the management of PFCD has evolved in terms of the multidisciplinary approach involving gastroenterologists and colorectal surgeons. However, the highest fistula healing rates, even combining surgical and anti-TNF agents, reaches 50% of treated patients. More recently, the administration of mesenchymal stem cells (MSCs) have shown notable promising results in the treatment of PFCD. The aim of this review is to describe the rationale and the possible mechanism of action of MSC application for PFCD and the most recent results of randomized clinical trials. Furthermore, the unmet needs of the current administration process and the expected next steps to improve the outcomes will be addressed.https://www.mdpi.com/2073-4409/8/7/764Crohn’s diseasestem cellsperianalfistula |
| spellingShingle | Michele Carvello Amy Lightner Takayuki Yamamoto Paulo Gustavo Kotze Antonino Spinelli Mesenchymal Stem Cells for Perianal Crohn’s Disease Cells Crohn’s disease stem cells perianal fistula |
| title | Mesenchymal Stem Cells for Perianal Crohn’s Disease |
| title_full | Mesenchymal Stem Cells for Perianal Crohn’s Disease |
| title_fullStr | Mesenchymal Stem Cells for Perianal Crohn’s Disease |
| title_full_unstemmed | Mesenchymal Stem Cells for Perianal Crohn’s Disease |
| title_short | Mesenchymal Stem Cells for Perianal Crohn’s Disease |
| title_sort | mesenchymal stem cells for perianal crohn s disease |
| topic | Crohn’s disease stem cells perianal fistula |
| url | https://www.mdpi.com/2073-4409/8/7/764 |
| work_keys_str_mv | AT michelecarvello mesenchymalstemcellsforperianalcrohnsdisease AT amylightner mesenchymalstemcellsforperianalcrohnsdisease AT takayukiyamamoto mesenchymalstemcellsforperianalcrohnsdisease AT paulogustavokotze mesenchymalstemcellsforperianalcrohnsdisease AT antoninospinelli mesenchymalstemcellsforperianalcrohnsdisease |