Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems.
The mammalian main olfactory system contains several subsystems that differ not only in the receptors they express and the glomerular targets they innervate within the main olfactory bulb (MOB), but also in the strategies they use to process odor information. The canonical main olfactory system empl...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5130179?pdf=render |
| _version_ | 1828407166357209088 |
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| author | Cedric R Uytingco Adam C Puche Steven D Munger |
| author_facet | Cedric R Uytingco Adam C Puche Steven D Munger |
| author_sort | Cedric R Uytingco |
| collection | DOAJ |
| description | The mammalian main olfactory system contains several subsystems that differ not only in the receptors they express and the glomerular targets they innervate within the main olfactory bulb (MOB), but also in the strategies they use to process odor information. The canonical main olfactory system employs a combinatorial coding strategy that represents odorant identity as a pattern of glomerular activity. By contrast, the "GC-D/necklace" olfactory subsystem-formed by olfactory sensory neurons expressing the receptor guanylyl cyclase GC-D and their target necklace glomeruli (NGs) encircling the caudal MOB-is critical for the detection of a small number of semiochemicals that promote the acquisition of food preferences. The formation of these socially-transmitted food preferences requires the animal to integrate information about two types of olfactory stimuli: these specialized social chemosignals and the food odors themselves. However, the neural mechanisms with which the GC-D/necklace subsystem processes this information are unclear. We used stimulus-induced increases in intrinsic fluorescence signals to map functional circuitry associated with NGs and canonical glomeruli (CGs) in the MOB. As expected, CG-associated activity spread laterally through both the glomerular and external plexiform layers associated with activated glomeruli. Activation of CGs or NGs resulted in activity spread between the two types of glomeruli; there was no evidence of preferential connectivity between individual necklace glomeruli. These results support previous anatomical findings that suggest the canonical and GC-D/necklace subsystems are functionally connected and may integrate general odor and semiochemical information in the MOB. |
| first_indexed | 2024-12-10T11:21:32Z |
| format | Article |
| id | doaj.art-6229555442e346d886ce213b641683e4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T11:21:32Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6229555442e346d886ce213b641683e42022-12-22T01:50:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016534310.1371/journal.pone.0165343Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems.Cedric R UytingcoAdam C PucheSteven D MungerThe mammalian main olfactory system contains several subsystems that differ not only in the receptors they express and the glomerular targets they innervate within the main olfactory bulb (MOB), but also in the strategies they use to process odor information. The canonical main olfactory system employs a combinatorial coding strategy that represents odorant identity as a pattern of glomerular activity. By contrast, the "GC-D/necklace" olfactory subsystem-formed by olfactory sensory neurons expressing the receptor guanylyl cyclase GC-D and their target necklace glomeruli (NGs) encircling the caudal MOB-is critical for the detection of a small number of semiochemicals that promote the acquisition of food preferences. The formation of these socially-transmitted food preferences requires the animal to integrate information about two types of olfactory stimuli: these specialized social chemosignals and the food odors themselves. However, the neural mechanisms with which the GC-D/necklace subsystem processes this information are unclear. We used stimulus-induced increases in intrinsic fluorescence signals to map functional circuitry associated with NGs and canonical glomeruli (CGs) in the MOB. As expected, CG-associated activity spread laterally through both the glomerular and external plexiform layers associated with activated glomeruli. Activation of CGs or NGs resulted in activity spread between the two types of glomeruli; there was no evidence of preferential connectivity between individual necklace glomeruli. These results support previous anatomical findings that suggest the canonical and GC-D/necklace subsystems are functionally connected and may integrate general odor and semiochemical information in the MOB.http://europepmc.org/articles/PMC5130179?pdf=render |
| spellingShingle | Cedric R Uytingco Adam C Puche Steven D Munger Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems. PLoS ONE |
| title | Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems. |
| title_full | Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems. |
| title_fullStr | Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems. |
| title_full_unstemmed | Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems. |
| title_short | Interglomerular Connectivity within the Canonical and GC-D/Necklace Olfactory Subsystems. |
| title_sort | interglomerular connectivity within the canonical and gc d necklace olfactory subsystems |
| url | http://europepmc.org/articles/PMC5130179?pdf=render |
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