Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress
Oxidative stress is caused by an imbalance in cellular redox state due to the accumulation of reactive oxygen species (ROS). While homeostatic levels of ROS are important for cell physiology and signaling, excess ROS can induce a variety of negative effects ranging from damage to biological macromol...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/5/981 |
| _version_ | 1797601334185164800 |
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| author | Gideon Ong Susan E. Logue |
| author_facet | Gideon Ong Susan E. Logue |
| author_sort | Gideon Ong |
| collection | DOAJ |
| description | Oxidative stress is caused by an imbalance in cellular redox state due to the accumulation of reactive oxygen species (ROS). While homeostatic levels of ROS are important for cell physiology and signaling, excess ROS can induce a variety of negative effects ranging from damage to biological macromolecules to cell death. Additionally, oxidative stress can disrupt the function of redox-sensitive organelles including the mitochondria and endoplasmic reticulum (ER). In the case of the ER, the accumulation of misfolded proteins can arise due to oxidative stress, leading to the onset of ER stress. To combat ER stress, cells initiate a highly conserved stress response called the unfolded protein response (UPR). While UPR signaling, within the context of resolving ER stress, is well characterised, how UPR mediators respond to and influence oxidative stress is less defined. In this review, we evaluate the interplay between oxidative stress, ER stress and UPR signaling networks. Specifically, we assess how UPR signaling mediators can influence antioxidant responses. |
| first_indexed | 2024-03-11T03:59:33Z |
| format | Article |
| id | doaj.art-622b75bf920549c9901b1e707cb35c68 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T03:59:33Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-622b75bf920549c9901b1e707cb35c682023-11-18T00:13:41ZengMDPI AGAntioxidants2076-39212023-04-0112598110.3390/antiox12050981Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative StressGideon Ong0Susan E. Logue1Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, CanadaDepartment of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, CanadaOxidative stress is caused by an imbalance in cellular redox state due to the accumulation of reactive oxygen species (ROS). While homeostatic levels of ROS are important for cell physiology and signaling, excess ROS can induce a variety of negative effects ranging from damage to biological macromolecules to cell death. Additionally, oxidative stress can disrupt the function of redox-sensitive organelles including the mitochondria and endoplasmic reticulum (ER). In the case of the ER, the accumulation of misfolded proteins can arise due to oxidative stress, leading to the onset of ER stress. To combat ER stress, cells initiate a highly conserved stress response called the unfolded protein response (UPR). While UPR signaling, within the context of resolving ER stress, is well characterised, how UPR mediators respond to and influence oxidative stress is less defined. In this review, we evaluate the interplay between oxidative stress, ER stress and UPR signaling networks. Specifically, we assess how UPR signaling mediators can influence antioxidant responses.https://www.mdpi.com/2076-3921/12/5/981antioxidantsendoplasmic reticulumreactive oxygen speciesunfolded protein response |
| spellingShingle | Gideon Ong Susan E. Logue Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress Antioxidants antioxidants endoplasmic reticulum reactive oxygen species unfolded protein response |
| title | Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress |
| title_full | Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress |
| title_fullStr | Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress |
| title_full_unstemmed | Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress |
| title_short | Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress |
| title_sort | unfolding the interactions between endoplasmic reticulum stress and oxidative stress |
| topic | antioxidants endoplasmic reticulum reactive oxygen species unfolded protein response |
| url | https://www.mdpi.com/2076-3921/12/5/981 |
| work_keys_str_mv | AT gideonong unfoldingtheinteractionsbetweenendoplasmicreticulumstressandoxidativestress AT susanelogue unfoldingtheinteractionsbetweenendoplasmicreticulumstressandoxidativestress |