Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development
Toxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the abilit...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Online Access: | https://www.mdpi.com/2073-4409/9/4/901 |
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| author | David R. Wallace Yasmeen M. Taalab Sarah Heinze Blanka Tariba Lovaković Alica Pizent Elisavet Renieri Aristidis Tsatsakis Ammad Ahmad Farooqi Dragana Javorac Milena Andjelkovic Zorica Bulat Biljana Antonijević Aleksandra Buha Djordjevic |
| author_facet | David R. Wallace Yasmeen M. Taalab Sarah Heinze Blanka Tariba Lovaković Alica Pizent Elisavet Renieri Aristidis Tsatsakis Ammad Ahmad Farooqi Dragana Javorac Milena Andjelkovic Zorica Bulat Biljana Antonijević Aleksandra Buha Djordjevic |
| author_sort | David R. Wallace |
| collection | DOAJ |
| description | Toxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)—short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain—a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs). |
| first_indexed | 2024-03-10T20:37:45Z |
| format | Article |
| id | doaj.art-622c45fe79d8410487f00eabf7890b95 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T20:37:45Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-622c45fe79d8410487f00eabf7890b952023-11-19T20:54:12ZengMDPI AGCells2073-44092020-04-019490110.3390/cells9040901Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease DevelopmentDavid R. Wallace0Yasmeen M. Taalab1Sarah Heinze2Blanka Tariba Lovaković3Alica Pizent4Elisavet Renieri5Aristidis Tsatsakis6Ammad Ahmad Farooqi7Dragana Javorac8Milena Andjelkovic9Zorica Bulat10Biljana Antonijević11Aleksandra Buha Djordjevic12School of Biomedical Science, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, USAForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Dakahlia Governate 35516, EgyptInstitute of Forensic and Traffic Medicine, University of Heidelberg, Voßstraße 2, 69115 Heidelberg, GermanyAnalytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000 Zagreb, CroatiaAnalytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000 Zagreb, CroatiaCentre of Toxicology Science and Research, University of Crete, School of Medicine, 71601 Heraklion, GreeceCentre of Toxicology Science and Research, University of Crete, School of Medicine, 71601 Heraklion, GreeceInstitute of Biomedical and Genetic engineering, 54000 Islamabad, PakistanDepartment of Toxicology “Akademik Danilo Soldatović”, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Toxicology “Akademik Danilo Soldatović”, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Toxicology “Akademik Danilo Soldatović”, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Toxicology “Akademik Danilo Soldatović”, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Toxicology “Akademik Danilo Soldatović”, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaToxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)—short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain—a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs).https://www.mdpi.com/2073-4409/9/4/901miRNAgene expressioncadmiumleadarsenicmercury |
| spellingShingle | David R. Wallace Yasmeen M. Taalab Sarah Heinze Blanka Tariba Lovaković Alica Pizent Elisavet Renieri Aristidis Tsatsakis Ammad Ahmad Farooqi Dragana Javorac Milena Andjelkovic Zorica Bulat Biljana Antonijević Aleksandra Buha Djordjevic Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development Cells miRNA gene expression cadmium lead arsenic mercury |
| title | Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development |
| title_full | Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development |
| title_fullStr | Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development |
| title_full_unstemmed | Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development |
| title_short | Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development |
| title_sort | toxic metal induced alteration in mirna expression profile as a proposed mechanism for disease development |
| topic | miRNA gene expression cadmium lead arsenic mercury |
| url | https://www.mdpi.com/2073-4409/9/4/901 |
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