Evaluation of the Immunomodulatory Effects of Fucoidan Derived from <i>Cladosiphon Okamuranus</i> Tokida in Mice
Okinawa mozuku (<i>Cladosiphon okamuranus</i> Tokida) is an edible seaweed classified as brown algae and is a native species of the Ryukyu Islands in Japan. In recent years, the genomic decoding of Okinawa mozuku has been completed. Previous studies on the anti-inflammatory, antiviral, a...
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MDPI AG
2019-09-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/10/547 |
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| author | Makoto Tomori Takeaki Nagamine Tomofumi Miyamoto Masahiko Iha |
| author_facet | Makoto Tomori Takeaki Nagamine Tomofumi Miyamoto Masahiko Iha |
| author_sort | Makoto Tomori |
| collection | DOAJ |
| description | Okinawa mozuku (<i>Cladosiphon okamuranus</i> Tokida) is an edible seaweed classified as brown algae and is a native species of the Ryukyu Islands in Japan. In recent years, the genomic decoding of Okinawa mozuku has been completed. Previous studies on the anti-inflammatory, antiviral, and antitumor properties of Okinawa mozuku have suggested that it affects the regulation of cellular and humoral immunity. The aim of the present study was to examine the immunoregulatory effect of fucoidan derived from Okinawa mozuku in mice. A product containing fucoidan (purity, 88.3%; molecular weight, 49.8 kDa) was developed from Okinawa mozuku and tested for its immunoregulatory effects in mice. The experimental animals were 8-week-old female BALB/c mice to which fucoidan (0, 102.5, 205.0, 410.0, and 1025.0 mg/kg) was administered orally continuously for six weeks. Immune cell proliferation, cytokine production, macrophage phagocytosis, and serum antibody concentration were measured. We found that immune cell proliferation, interleukin (IL)-2, macrophage phagocytes, and serum antibodies (IgM, -G, -A) increased significantly, but IL-4, -5, and IgE decreased significantly. These results indicated that fucoidan modulated cellular and humoral immunity. |
| first_indexed | 2024-04-13T00:52:06Z |
| format | Article |
| id | doaj.art-622ebdb212994158a6d27675ef1db9b9 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T00:52:06Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-622ebdb212994158a6d27675ef1db9b92022-12-22T03:09:51ZengMDPI AGMarine Drugs1660-33972019-09-01171054710.3390/md17100547md17100547Evaluation of the Immunomodulatory Effects of Fucoidan Derived from <i>Cladosiphon Okamuranus</i> Tokida in MiceMakoto Tomori0Takeaki Nagamine1Tomofumi Miyamoto2Masahiko Iha3South Product Co., Ltd., Uruma 904-2234, JapanDepartment of Health and Nutrition, Takasaki University of Health Science, Takasaki 370-0036, JapanGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, JapanSouth Product Co., Ltd., Uruma 904-2234, JapanOkinawa mozuku (<i>Cladosiphon okamuranus</i> Tokida) is an edible seaweed classified as brown algae and is a native species of the Ryukyu Islands in Japan. In recent years, the genomic decoding of Okinawa mozuku has been completed. Previous studies on the anti-inflammatory, antiviral, and antitumor properties of Okinawa mozuku have suggested that it affects the regulation of cellular and humoral immunity. The aim of the present study was to examine the immunoregulatory effect of fucoidan derived from Okinawa mozuku in mice. A product containing fucoidan (purity, 88.3%; molecular weight, 49.8 kDa) was developed from Okinawa mozuku and tested for its immunoregulatory effects in mice. The experimental animals were 8-week-old female BALB/c mice to which fucoidan (0, 102.5, 205.0, 410.0, and 1025.0 mg/kg) was administered orally continuously for six weeks. Immune cell proliferation, cytokine production, macrophage phagocytosis, and serum antibody concentration were measured. We found that immune cell proliferation, interleukin (IL)-2, macrophage phagocytes, and serum antibodies (IgM, -G, -A) increased significantly, but IL-4, -5, and IgE decreased significantly. These results indicated that fucoidan modulated cellular and humoral immunity.https://www.mdpi.com/1660-3397/17/10/547<i>Cladosiphon okamuranus</i>fucoidanimmune cell proliferationimmunomodulatory |
| spellingShingle | Makoto Tomori Takeaki Nagamine Tomofumi Miyamoto Masahiko Iha Evaluation of the Immunomodulatory Effects of Fucoidan Derived from <i>Cladosiphon Okamuranus</i> Tokida in Mice Marine Drugs <i>Cladosiphon okamuranus</i> fucoidan immune cell proliferation immunomodulatory |
| title | Evaluation of the Immunomodulatory Effects of Fucoidan Derived from <i>Cladosiphon Okamuranus</i> Tokida in Mice |
| title_full | Evaluation of the Immunomodulatory Effects of Fucoidan Derived from <i>Cladosiphon Okamuranus</i> Tokida in Mice |
| title_fullStr | Evaluation of the Immunomodulatory Effects of Fucoidan Derived from <i>Cladosiphon Okamuranus</i> Tokida in Mice |
| title_full_unstemmed | Evaluation of the Immunomodulatory Effects of Fucoidan Derived from <i>Cladosiphon Okamuranus</i> Tokida in Mice |
| title_short | Evaluation of the Immunomodulatory Effects of Fucoidan Derived from <i>Cladosiphon Okamuranus</i> Tokida in Mice |
| title_sort | evaluation of the immunomodulatory effects of fucoidan derived from i cladosiphon okamuranus i tokida in mice |
| topic | <i>Cladosiphon okamuranus</i> fucoidan immune cell proliferation immunomodulatory |
| url | https://www.mdpi.com/1660-3397/17/10/547 |
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