Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation

Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation

Chronic alcohol consumption causes liver steatosis, cell death, and inflammation. Melatonin (MLT) is reported to alleviate alcoholic liver disease (ALD)-induced injury. However, its direct regulating targets in hepatocytes are not fully understood. In the current study, a cell-based screening model...

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Bibliographic Details
Main Authors: Zhaodi Che, Yali Song, Chengfang Xu, Wei Li, Zhiyong Dong, Cunchuan Wang, Yixing Ren, Kwok-Fai So, George L. Tipoe, Fei Wang, Jia Xiao
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Alcoholic liver disease
Melatonin
Binding receptor
TERT
EGFR
BRG1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522002945

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