Cancer risk and disease burden of dietary acrylamide exposure in China, 2016
Background: Acrylamide is widely found in food as a side-product of high-temperature heating of starch-rich food. It has attracted much attention because of its neurotoxicity and carcinogenicity. However, the cancer risk and disease burden of dietary acrylamide exposure have not been quantified in C...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322003918 |
| _version_ | 1828366273677885440 |
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| author | Yiling Li Jialin Liu Yibaina Wang Sheng Wei |
| author_facet | Yiling Li Jialin Liu Yibaina Wang Sheng Wei |
| author_sort | Yiling Li |
| collection | DOAJ |
| description | Background: Acrylamide is widely found in food as a side-product of high-temperature heating of starch-rich food. It has attracted much attention because of its neurotoxicity and carcinogenicity. However, the cancer risk and disease burden of dietary acrylamide exposure have not been quantified in China. Objective: To estimate the cancer risk and the disease burden attributable to dietary acrylamide exposure and quantify its health hazards. Method: We first performed an exposure assessment of acrylamide in food, based on which the incremental excess lifetime cancer risk (ELCR) was calculated for cancer risk assessment. The DisMod Ⅱ software and the DALY calculator in R were used to calculate the disease burden due to dietary acrylamide exposure. Results: Average dietary acrylamide exposure in males was 0.1531 μg·kg−1·d−1 and that in females was 0.1554 μg·kg−1·d−1, resulting in an ELCR of 7.81 × 10−5 for males and 7.92 × 10−5 for females in China. The dietary acrylamide exposure resulted in about 23,688.09 DALYs of cancers among the Chinese population in 2016, including 1331.93 DALYs of breast cancer, 243.32 DALYs of endometrial cancer, 248.91 DALYs of ovarian cancer, and 176.28 DALYs of kidney cancer, respectively. Conclusion: The health hazards of dietary acrylamide exposure deserve attention. The burden of disease assessment could quantify the health hazards of food contaminants for prioritizing policies. |
| first_indexed | 2024-04-14T05:42:06Z |
| format | Article |
| id | doaj.art-62314cff9e884c81b4a3b65ddd3f650c |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-14T05:42:06Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-62314cff9e884c81b4a3b65ddd3f650c2022-12-22T02:09:24ZengElsevierEcotoxicology and Environmental Safety0147-65132022-06-01238113551Cancer risk and disease burden of dietary acrylamide exposure in China, 2016Yiling Li0Jialin Liu1Yibaina Wang2Sheng Wei3Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR ChinaNational Food Safety Risk Assessment Center, Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing 10022, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China; Correspondence to: School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.Background: Acrylamide is widely found in food as a side-product of high-temperature heating of starch-rich food. It has attracted much attention because of its neurotoxicity and carcinogenicity. However, the cancer risk and disease burden of dietary acrylamide exposure have not been quantified in China. Objective: To estimate the cancer risk and the disease burden attributable to dietary acrylamide exposure and quantify its health hazards. Method: We first performed an exposure assessment of acrylamide in food, based on which the incremental excess lifetime cancer risk (ELCR) was calculated for cancer risk assessment. The DisMod Ⅱ software and the DALY calculator in R were used to calculate the disease burden due to dietary acrylamide exposure. Results: Average dietary acrylamide exposure in males was 0.1531 μg·kg−1·d−1 and that in females was 0.1554 μg·kg−1·d−1, resulting in an ELCR of 7.81 × 10−5 for males and 7.92 × 10−5 for females in China. The dietary acrylamide exposure resulted in about 23,688.09 DALYs of cancers among the Chinese population in 2016, including 1331.93 DALYs of breast cancer, 243.32 DALYs of endometrial cancer, 248.91 DALYs of ovarian cancer, and 176.28 DALYs of kidney cancer, respectively. Conclusion: The health hazards of dietary acrylamide exposure deserve attention. The burden of disease assessment could quantify the health hazards of food contaminants for prioritizing policies.http://www.sciencedirect.com/science/article/pii/S0147651322003918AcrylamideChinaExposure assessmentCancer riskDisease burden |
| spellingShingle | Yiling Li Jialin Liu Yibaina Wang Sheng Wei Cancer risk and disease burden of dietary acrylamide exposure in China, 2016 Ecotoxicology and Environmental Safety Acrylamide China Exposure assessment Cancer risk Disease burden |
| title | Cancer risk and disease burden of dietary acrylamide exposure in China, 2016 |
| title_full | Cancer risk and disease burden of dietary acrylamide exposure in China, 2016 |
| title_fullStr | Cancer risk and disease burden of dietary acrylamide exposure in China, 2016 |
| title_full_unstemmed | Cancer risk and disease burden of dietary acrylamide exposure in China, 2016 |
| title_short | Cancer risk and disease burden of dietary acrylamide exposure in China, 2016 |
| title_sort | cancer risk and disease burden of dietary acrylamide exposure in china 2016 |
| topic | Acrylamide China Exposure assessment Cancer risk Disease burden |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322003918 |
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