A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum
Background: Molluscum contagiosum (MC) is a common self-limiting viral infection of the skin. Many therapeutic agents have been used for it with varying success rates. Objective: To evaluate and compare the efficacy and safety profile of topical 20% glycolic acid and 30% salicylic acid in the treatm...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Cutaneous and Aesthetic Surgery |
| Subjects: | |
| Online Access: | http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=3;spage=249;epage=253;aulast=Nai |
| _version_ | 1811180093868867584 |
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| author | Radhe S Nai Bhikam C Ghiya Alpana K Mohta Rajesh D Mehta |
| author_facet | Radhe S Nai Bhikam C Ghiya Alpana K Mohta Rajesh D Mehta |
| author_sort | Radhe S Nai |
| collection | DOAJ |
| description | Background: Molluscum contagiosum (MC) is a common self-limiting viral infection of the skin. Many therapeutic agents have been used for it with varying success rates. Objective: To evaluate and compare the efficacy and safety profile of topical 20% glycolic acid and 30% salicylic acid in the treatment of MC in pediatric patients. Materials and Methods: All patients of MC between 1 and 15 years of age attending the outpatient department of dermatology were randomized into two treatment groups A and B. Group A was treated with 20% glycolic acid solution, and group B was treated with 30% salicylic acid solution daily for 4 weeks. Parents of patients were instructed to apply the medication once daily at night for 1 h on the lesions only. The assessment of response and side effects were analyzed in all the patients weekly for 4 weeks during the daily treatment protocol. Follow-up was done monthly for 3 months after the completion of therapy. Results: At the end of 4 weeks, group A patients (60 patients) were treated with 20% glycolic acid out of which 34 (56.66%) patients had a complete clearance of lesions. Group B patients were treated with 30% salicylic acid out of which 38 (63.33%) had a complete clearance of lesions. Secondary bacterial infection was the most common side effect followed by postinflammatory hyperpigmentation in both groups. Conclusion: 30% salicylic acid was found to be more effective and has less side-effect profile in the treatment of MC than 20% glycolic acid. |
| first_indexed | 2024-04-11T06:45:45Z |
| format | Article |
| id | doaj.art-6232612372b848c69fc4e2b11a045329 |
| institution | Directory Open Access Journal |
| issn | 0974-2077 |
| language | English |
| last_indexed | 2024-04-11T06:45:45Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cutaneous and Aesthetic Surgery |
| spelling | doaj.art-6232612372b848c69fc4e2b11a0453292022-12-22T04:39:22ZengWolters Kluwer Medknow PublicationsJournal of Cutaneous and Aesthetic Surgery0974-20772022-01-0115324925310.4103/JCAS.JCAS_198_21A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosumRadhe S NaiBhikam C GhiyaAlpana K MohtaRajesh D MehtaBackground: Molluscum contagiosum (MC) is a common self-limiting viral infection of the skin. Many therapeutic agents have been used for it with varying success rates. Objective: To evaluate and compare the efficacy and safety profile of topical 20% glycolic acid and 30% salicylic acid in the treatment of MC in pediatric patients. Materials and Methods: All patients of MC between 1 and 15 years of age attending the outpatient department of dermatology were randomized into two treatment groups A and B. Group A was treated with 20% glycolic acid solution, and group B was treated with 30% salicylic acid solution daily for 4 weeks. Parents of patients were instructed to apply the medication once daily at night for 1 h on the lesions only. The assessment of response and side effects were analyzed in all the patients weekly for 4 weeks during the daily treatment protocol. Follow-up was done monthly for 3 months after the completion of therapy. Results: At the end of 4 weeks, group A patients (60 patients) were treated with 20% glycolic acid out of which 34 (56.66%) patients had a complete clearance of lesions. Group B patients were treated with 30% salicylic acid out of which 38 (63.33%) had a complete clearance of lesions. Secondary bacterial infection was the most common side effect followed by postinflammatory hyperpigmentation in both groups. Conclusion: 30% salicylic acid was found to be more effective and has less side-effect profile in the treatment of MC than 20% glycolic acid.http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=3;spage=249;epage=253;aulast=Nai20% glycolic acid30% salicylic acidmolluscum contagiosum |
| spellingShingle | Radhe S Nai Bhikam C Ghiya Alpana K Mohta Rajesh D Mehta A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum Journal of Cutaneous and Aesthetic Surgery 20% glycolic acid 30% salicylic acid molluscum contagiosum |
| title | A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum |
| title_full | A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum |
| title_fullStr | A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum |
| title_full_unstemmed | A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum |
| title_short | A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum |
| title_sort | randomized control trial of 20 glycolic acid versus 30 salicylic acid in the management of molluscum contagiosum |
| topic | 20% glycolic acid 30% salicylic acid molluscum contagiosum |
| url | http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=3;spage=249;epage=253;aulast=Nai |
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