Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study
Objectives: We sought to assess the efficacy, safety and short-term clinical outcome of very high-power short-duration (vHP-SD) radiofrequency (RF) catheter ablation for the treatment of idiopathic PVCs originating from the cardiac outflow tract (OT). Background: Power-controlled RF ablation is a wi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906722000914 |
| _version_ | 1818007724341854208 |
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| author | Christian-Hendrik Heeger Sorin S. Popescu Bettina Kirstein Sascha Hatahet Anna Traub Huong-Lan Phan Marcel Feher Gabriele D́Ambrosio Ahmad Keelani Michael Schlüter Julia Vogler Charlotte Eitel Karl-Heinz Kuck Roland R. Tilz |
| author_facet | Christian-Hendrik Heeger Sorin S. Popescu Bettina Kirstein Sascha Hatahet Anna Traub Huong-Lan Phan Marcel Feher Gabriele D́Ambrosio Ahmad Keelani Michael Schlüter Julia Vogler Charlotte Eitel Karl-Heinz Kuck Roland R. Tilz |
| author_sort | Christian-Hendrik Heeger |
| collection | DOAJ |
| description | Objectives: We sought to assess the efficacy, safety and short-term clinical outcome of very high-power short-duration (vHP-SD) radiofrequency (RF) catheter ablation for the treatment of idiopathic PVCs originating from the cardiac outflow tract (OT). Background: Power-controlled RF ablation is a widely used technique for the treatment of premature ventricular contractions (PVCs). A novel ablation catheter offers three microelectrodes and six thermocouples at its tip and provides temperature-controlled vHP-SD (90 Watts/4 s,) with the opportunity to switch to moderate-power mode. Methods: In this pilot study, twenty-four consecutive, prospectively enrolled patients underwent PVC ablation utilizing the vHP-SD ablation (study group) and were compared with 24 consecutive patients previously treated with power-controlled ablation (control group). Each group included 12 patients with PVCs originating from the right ventricular OT (RVOT) and 12 patients with PVCs originating from the left ventricular OT (LVOT). The acute endpoint was PVC elimination and was achieved in all patients. Results: In 16/24 (67%) patients (study group) it was achieved by using vHP-SD only. The median RF delivery time was 52 (interquartile range [IQR] 16, 156) seconds (study group) and 350 (IQR 240, 442) seconds (control group, p < 0.0001). No difference was observed regarding procedure duration (p = 0.489) as well as 6-months follow-up (p = 0.712). One (4%, study group) and 2 (8%, control group) severe adverse events occured (p = 0.551). Conclusion: In this study, vHP-SD PVC ablation was similarly effective and safe as compared to conventional power-controlled ablation. The RF time was significantly shorter. |
| first_indexed | 2024-04-14T05:19:26Z |
| format | Article |
| id | doaj.art-62328845c2f6489fad816cffbaf912a2 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-14T05:19:26Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-62328845c2f6489fad816cffbaf912a22022-12-22T02:10:14ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672022-06-0140101042Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC studyChristian-Hendrik Heeger0Sorin S. Popescu1Bettina Kirstein2Sascha Hatahet3Anna Traub4Huong-Lan Phan5Marcel Feher6Gabriele D́Ambrosio7Ahmad Keelani8Michael Schlüter9Julia Vogler10Charlotte Eitel11Karl-Heinz Kuck12Roland R. Tilz13Department of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, Germany; German Center for Cardiovascular Research (DZHK), Partner Site, Lübeck, Germany; Corresponding authors at: Division of Electrophysiology, Medizinische Klinik II (Kardiologie, Angiologie, Intensivmedizin), Universitäres Herzzentrum Lübeck, Universitätsklinikum Schleswig-Holstein (UKSH), Ratzeburger Allee 160, D-23538 Lübeck, Germany.Department of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, Germany; Carol Davila, University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, GermanyLANS Cardio, Stephansplatz 5, 20354 Hamburg, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, Germany; LANS Cardio, Stephansplatz 5, 20354 Hamburg, GermanyDepartment of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, Germany; German Center for Cardiovascular Research (DZHK), Partner Site, Lübeck, Germany; Corresponding authors at: Division of Electrophysiology, Medizinische Klinik II (Kardiologie, Angiologie, Intensivmedizin), Universitäres Herzzentrum Lübeck, Universitätsklinikum Schleswig-Holstein (UKSH), Ratzeburger Allee 160, D-23538 Lübeck, Germany.Objectives: We sought to assess the efficacy, safety and short-term clinical outcome of very high-power short-duration (vHP-SD) radiofrequency (RF) catheter ablation for the treatment of idiopathic PVCs originating from the cardiac outflow tract (OT). Background: Power-controlled RF ablation is a widely used technique for the treatment of premature ventricular contractions (PVCs). A novel ablation catheter offers three microelectrodes and six thermocouples at its tip and provides temperature-controlled vHP-SD (90 Watts/4 s,) with the opportunity to switch to moderate-power mode. Methods: In this pilot study, twenty-four consecutive, prospectively enrolled patients underwent PVC ablation utilizing the vHP-SD ablation (study group) and were compared with 24 consecutive patients previously treated with power-controlled ablation (control group). Each group included 12 patients with PVCs originating from the right ventricular OT (RVOT) and 12 patients with PVCs originating from the left ventricular OT (LVOT). The acute endpoint was PVC elimination and was achieved in all patients. Results: In 16/24 (67%) patients (study group) it was achieved by using vHP-SD only. The median RF delivery time was 52 (interquartile range [IQR] 16, 156) seconds (study group) and 350 (IQR 240, 442) seconds (control group, p < 0.0001). No difference was observed regarding procedure duration (p = 0.489) as well as 6-months follow-up (p = 0.712). One (4%, study group) and 2 (8%, control group) severe adverse events occured (p = 0.551). Conclusion: In this study, vHP-SD PVC ablation was similarly effective and safe as compared to conventional power-controlled ablation. The RF time was significantly shorter.http://www.sciencedirect.com/science/article/pii/S2352906722000914Very high-power short-duration ablationPremature ventricular contractionCatheter ablationCardiac outflow tract |
| spellingShingle | Christian-Hendrik Heeger Sorin S. Popescu Bettina Kirstein Sascha Hatahet Anna Traub Huong-Lan Phan Marcel Feher Gabriele D́Ambrosio Ahmad Keelani Michael Schlüter Julia Vogler Charlotte Eitel Karl-Heinz Kuck Roland R. Tilz Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study International Journal of Cardiology: Heart & Vasculature Very high-power short-duration ablation Premature ventricular contraction Catheter ablation Cardiac outflow tract |
| title | Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study |
| title_full | Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study |
| title_fullStr | Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study |
| title_full_unstemmed | Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study |
| title_short | Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study |
| title_sort | very high power short duration ablation for treatment of premature ventricular contractions the fast and furious pvc study |
| topic | Very high-power short-duration ablation Premature ventricular contraction Catheter ablation Cardiac outflow tract |
| url | http://www.sciencedirect.com/science/article/pii/S2352906722000914 |
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