Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis
Objective: To qualitative and quantitatively review published literature assessing the oxidative stress marker malondialdehyde (MDA) in oral squamous cell carcinoma (OSCC). Methodology: Pubmed (MeSH), Science Direct, Scopus, Web of Science, Willey Online Library, Cochrane, and Cross Reference were s...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/43/2/72 |
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| author | Khadijah Mohideen Uma Sudhakar Thayumanavan Balakrishnan Mazen A. Almasri Manea Musa Al-Ahmari Hajar Saeed Al Dira Malath Suhluli Alok Dubey Sheetal Mujoo Zohaib Khurshid A. Thirumal Raj Shankargouda Patil |
| author_facet | Khadijah Mohideen Uma Sudhakar Thayumanavan Balakrishnan Mazen A. Almasri Manea Musa Al-Ahmari Hajar Saeed Al Dira Malath Suhluli Alok Dubey Sheetal Mujoo Zohaib Khurshid A. Thirumal Raj Shankargouda Patil |
| author_sort | Khadijah Mohideen |
| collection | DOAJ |
| description | Objective: To qualitative and quantitatively review published literature assessing the oxidative stress marker malondialdehyde (MDA) in oral squamous cell carcinoma (OSCC). Methodology: Pubmed (MeSH), Science Direct, Scopus, Web of Science, Willey Online Library, Cochrane, and Cross Reference were searched for studies assessing MDA levels in OSCC samples. Results: From the 1008 articles identified, 849 were excluded based on title and abstract screening due to duplication and irrelevance to the topic of interest. Full-text assessment of the remaining 159 articles led to the inclusion of only 46 articles that satisfied the selection criteria. Of these, only 26 studies had data compatible for quantitative analysis. The MDA levels in OSCC groups are significantly increased (<i>p</i> < 0.00001) in plasma, serum, and saliva samples in the majority of the studies evaluated. In contrast, MDA levels in OSCC tissue samples are significantly attenuated (<i>p</i> < 0.00001) compared to healthy controls, supported by fewer studies. Conclusions: The augmented MDA levels in plasma, serum, and saliva samples of the OSCC reflect the heightened oxidative stress level accurately. Further studies are required to understand the attenuated MDA levels in the tissue samples of OSCC. Correlation analysis between MDA levels with established clinicopathological prognostic markers could aid in formulating oxidative stress-based prognostication and treatment planning. |
| first_indexed | 2024-03-10T07:47:23Z |
| format | Article |
| id | doaj.art-6234b52b64df40e9a071dc871714a5b2 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-10T07:47:23Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-6234b52b64df40e9a071dc871714a5b22023-11-22T12:31:19ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452021-08-014321019103510.3390/cimb43020072Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-AnalysisKhadijah Mohideen0Uma Sudhakar1Thayumanavan Balakrishnan2Mazen A. Almasri3Manea Musa Al-Ahmari4Hajar Saeed Al Dira5Malath Suhluli6Alok Dubey7Sheetal Mujoo8Zohaib Khurshid9A. Thirumal Raj10Shankargouda Patil11Department of Oral Pathology and Microbiology, Sathyabama Institute of Science and Technology, Sathyabama Dental College and Hospital, Chennai 600119, IndiaDepartment of Periodontics and Implantology, Dr. M.G.R. Educational and Research Institute, Thai Moogambigai Dental College and Hospital, Chennai 600095, IndiaDepartment of Oral Pathology and Microbiology, Sathyabama Institute of Science and Technology, Sathyabama Dental College and Hospital, Chennai 600119, IndiaDepartment of Oral Maxillofacial Surgery, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 61421, Saudi ArabiaCollege of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDental School, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDivision of Oral Medicine & Radiology College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, IndiaDivision of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi ArabiaObjective: To qualitative and quantitatively review published literature assessing the oxidative stress marker malondialdehyde (MDA) in oral squamous cell carcinoma (OSCC). Methodology: Pubmed (MeSH), Science Direct, Scopus, Web of Science, Willey Online Library, Cochrane, and Cross Reference were searched for studies assessing MDA levels in OSCC samples. Results: From the 1008 articles identified, 849 were excluded based on title and abstract screening due to duplication and irrelevance to the topic of interest. Full-text assessment of the remaining 159 articles led to the inclusion of only 46 articles that satisfied the selection criteria. Of these, only 26 studies had data compatible for quantitative analysis. The MDA levels in OSCC groups are significantly increased (<i>p</i> < 0.00001) in plasma, serum, and saliva samples in the majority of the studies evaluated. In contrast, MDA levels in OSCC tissue samples are significantly attenuated (<i>p</i> < 0.00001) compared to healthy controls, supported by fewer studies. Conclusions: The augmented MDA levels in plasma, serum, and saliva samples of the OSCC reflect the heightened oxidative stress level accurately. Further studies are required to understand the attenuated MDA levels in the tissue samples of OSCC. Correlation analysis between MDA levels with established clinicopathological prognostic markers could aid in formulating oxidative stress-based prognostication and treatment planning.https://www.mdpi.com/1467-3045/43/2/72oral squamous cell carcinomaoral canceroxidative stress |
| spellingShingle | Khadijah Mohideen Uma Sudhakar Thayumanavan Balakrishnan Mazen A. Almasri Manea Musa Al-Ahmari Hajar Saeed Al Dira Malath Suhluli Alok Dubey Sheetal Mujoo Zohaib Khurshid A. Thirumal Raj Shankargouda Patil Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis Current Issues in Molecular Biology oral squamous cell carcinoma oral cancer oxidative stress |
| title | Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis |
| title_full | Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis |
| title_fullStr | Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis |
| title_short | Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis |
| title_sort | malondialdehyde an oxidative stress marker in oral squamous cell carcinoma a systematic review and meta analysis |
| topic | oral squamous cell carcinoma oral cancer oxidative stress |
| url | https://www.mdpi.com/1467-3045/43/2/72 |
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