Transient hyperthermia protects against subsequent seizures and epilepsy-induced cell damage in the rat
Many mild preconditioning stress conditions, including physical and metabolic injuries, increase the resistance of neurons to subsequent more severe stresses of the same or different type. This “tolerance phenomenon” lasts one to several weeks, providing a unique opportunity to investigate endogenou...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2005-06-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996104002876 |
| _version_ | 1818721797617483776 |
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| author | Venceslas Duveau Sébastien Arthaud Henry Serre Alain Rougier Gildas Le Gal La Salle |
| author_facet | Venceslas Duveau Sébastien Arthaud Henry Serre Alain Rougier Gildas Le Gal La Salle |
| author_sort | Venceslas Duveau |
| collection | DOAJ |
| description | Many mild preconditioning stress conditions, including physical and metabolic injuries, increase the resistance of neurons to subsequent more severe stresses of the same or different type. This “tolerance phenomenon” lasts one to several weeks, providing a unique opportunity to investigate endogenous neuroprotective mechanisms. The aim of this study was to find a physiological and easily applicable preconditioning stimulus able to confer protection against convulsant-induced neuronal damage and seizures. We found that moderate transient hyperthermic preconditioning markedly reduced kainic-acid-induced neuronal cell loss and attenuated susceptibility to bicuculline-induced seizures. Prevention of cell damage (∼50%) was efficient both in vitro in organotypic hippocampal slice cultures and in vivo in adult rats. This protection lasted about 1 week and peaked 3 to 5 days after pretreatment. Unraveling the mechanisms of heat shock preconditioning-induced protection against epilepsy should lead to the development of new therapeutic strategies. |
| first_indexed | 2024-12-17T20:44:27Z |
| format | Article |
| id | doaj.art-6234f8c23aca4097915916f44f280e64 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T20:44:27Z |
| publishDate | 2005-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-6234f8c23aca4097915916f44f280e642022-12-21T21:33:12ZengElsevierNeurobiology of Disease1095-953X2005-06-01191142149Transient hyperthermia protects against subsequent seizures and epilepsy-induced cell damage in the ratVenceslas Duveau0Sébastien Arthaud1Henry Serre2Alain Rougier3Gildas Le Gal La Salle4Laboratoire d'Epileptologie Expérimentale et Clinique, Université Bordeaux 2, BP 78, 146, rue Léo Saignat, 33076 Bordeaux cedex, FranceLaboratoire d'Epileptologie Expérimentale et Clinique, Université Bordeaux 2, BP 78, 146, rue Léo Saignat, 33076 Bordeaux cedex, FranceLaboratoire d'Epileptologie Expérimentale et Clinique, Université Bordeaux 2, BP 78, 146, rue Léo Saignat, 33076 Bordeaux cedex, FranceLaboratoire d'Epileptologie Expérimentale et Clinique, Université Bordeaux 2, BP 78, 146, rue Léo Saignat, 33076 Bordeaux cedex, FranceCorresponding author. Fax: +33 5 56 51 52 48.; Laboratoire d'Epileptologie Expérimentale et Clinique, Université Bordeaux 2, BP 78, 146, rue Léo Saignat, 33076 Bordeaux cedex, FranceMany mild preconditioning stress conditions, including physical and metabolic injuries, increase the resistance of neurons to subsequent more severe stresses of the same or different type. This “tolerance phenomenon” lasts one to several weeks, providing a unique opportunity to investigate endogenous neuroprotective mechanisms. The aim of this study was to find a physiological and easily applicable preconditioning stimulus able to confer protection against convulsant-induced neuronal damage and seizures. We found that moderate transient hyperthermic preconditioning markedly reduced kainic-acid-induced neuronal cell loss and attenuated susceptibility to bicuculline-induced seizures. Prevention of cell damage (∼50%) was efficient both in vitro in organotypic hippocampal slice cultures and in vivo in adult rats. This protection lasted about 1 week and peaked 3 to 5 days after pretreatment. Unraveling the mechanisms of heat shock preconditioning-induced protection against epilepsy should lead to the development of new therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S0969996104002876EpilepsySeizuresNeuroprotectionToleranceHeat shockHyperthermia |
| spellingShingle | Venceslas Duveau Sébastien Arthaud Henry Serre Alain Rougier Gildas Le Gal La Salle Transient hyperthermia protects against subsequent seizures and epilepsy-induced cell damage in the rat Neurobiology of Disease Epilepsy Seizures Neuroprotection Tolerance Heat shock Hyperthermia |
| title | Transient hyperthermia protects against subsequent seizures and epilepsy-induced cell damage in the rat |
| title_full | Transient hyperthermia protects against subsequent seizures and epilepsy-induced cell damage in the rat |
| title_fullStr | Transient hyperthermia protects against subsequent seizures and epilepsy-induced cell damage in the rat |
| title_full_unstemmed | Transient hyperthermia protects against subsequent seizures and epilepsy-induced cell damage in the rat |
| title_short | Transient hyperthermia protects against subsequent seizures and epilepsy-induced cell damage in the rat |
| title_sort | transient hyperthermia protects against subsequent seizures and epilepsy induced cell damage in the rat |
| topic | Epilepsy Seizures Neuroprotection Tolerance Heat shock Hyperthermia |
| url | http://www.sciencedirect.com/science/article/pii/S0969996104002876 |
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