Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice
Abstract Sex differences in certain types of pain sensitivity and emotional responses have been previously reported. Synaptic plasticity is a key cellular mechanism for pain perception and emotional regulation, including long-term potentiation (LTP) and long-term depression (LTD). However, it is unc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-03-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13041-020-00583-8 |
| _version_ | 1819047754868981760 |
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| author | Ren-Hao Liu Man Xue Xu-Hui Li Min Zhuo |
| author_facet | Ren-Hao Liu Man Xue Xu-Hui Li Min Zhuo |
| author_sort | Ren-Hao Liu |
| collection | DOAJ |
| description | Abstract Sex differences in certain types of pain sensitivity and emotional responses have been previously reported. Synaptic plasticity is a key cellular mechanism for pain perception and emotional regulation, including long-term potentiation (LTP) and long-term depression (LTD). However, it is unclear whether there is a sex difference at synaptic level. Recent studies indicate that excitatory transmission and plasticity in the anterior cingulate cortex (ACC) are critical in chronic pain and pain related emotional responses. In the present study, we used 64-channel multielectrode (MED64) system to record synaptic plasticity in the ACC of male and female adult mice. We found that there was no significant difference in theta-burst stimulation (TBS)-induced LTP between female and male mice. Furthermore, the recruitment of inactive channels was also not different. For LTD, we found that LTD was greater in slices of ACC in male mice than female mice. Our results demonstrate that LTP in the ACC does not show any sex-related difference. |
| first_indexed | 2024-12-21T11:05:24Z |
| format | Article |
| id | doaj.art-62363b44af3b41389f8ca004985575b8 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-21T11:05:24Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-62363b44af3b41389f8ca004985575b82022-12-21T19:06:15ZengBMCMolecular Brain1756-66062020-03-0113111110.1186/s13041-020-00583-8Sex difference in synaptic plasticity in the anterior cingulate cortex of adult miceRen-Hao Liu0Man Xue1Xu-Hui Li2Min Zhuo3Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong UniversityCenter for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong UniversityCenter for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong UniversityCenter for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong UniversityAbstract Sex differences in certain types of pain sensitivity and emotional responses have been previously reported. Synaptic plasticity is a key cellular mechanism for pain perception and emotional regulation, including long-term potentiation (LTP) and long-term depression (LTD). However, it is unclear whether there is a sex difference at synaptic level. Recent studies indicate that excitatory transmission and plasticity in the anterior cingulate cortex (ACC) are critical in chronic pain and pain related emotional responses. In the present study, we used 64-channel multielectrode (MED64) system to record synaptic plasticity in the ACC of male and female adult mice. We found that there was no significant difference in theta-burst stimulation (TBS)-induced LTP between female and male mice. Furthermore, the recruitment of inactive channels was also not different. For LTD, we found that LTD was greater in slices of ACC in male mice than female mice. Our results demonstrate that LTP in the ACC does not show any sex-related difference.http://link.springer.com/article/10.1186/s13041-020-00583-8Sex differenceAnterior cingulate cortexLong-term potentiationLong-term depressionFemaleMale |
| spellingShingle | Ren-Hao Liu Man Xue Xu-Hui Li Min Zhuo Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice Molecular Brain Sex difference Anterior cingulate cortex Long-term potentiation Long-term depression Female Male |
| title | Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice |
| title_full | Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice |
| title_fullStr | Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice |
| title_full_unstemmed | Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice |
| title_short | Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice |
| title_sort | sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice |
| topic | Sex difference Anterior cingulate cortex Long-term potentiation Long-term depression Female Male |
| url | http://link.springer.com/article/10.1186/s13041-020-00583-8 |
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