Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study
Introduction: Quercetin is a polyphenolic flavonoid which has been used in traditional Chinese medicine as a natural therapeutic agent with a broad spectrum of activities (antioxidant, anticancer, neuroprotective, anti-inflammatory, antiviral and antibacterial). The aim of this study was to develop...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2019-03-01
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| Series: | Journal of Veterinary Research |
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| Online Access: | https://doi.org/10.2478/jvetres-2019-0013 |
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| author | Gbylik-Sikorska Małgorzata Gajda Anna Burmańczuk Artur Grabowski Tomasz Posyniak Andrzej |
| author_facet | Gbylik-Sikorska Małgorzata Gajda Anna Burmańczuk Artur Grabowski Tomasz Posyniak Andrzej |
| author_sort | Gbylik-Sikorska Małgorzata |
| collection | DOAJ |
| description | Introduction: Quercetin is a polyphenolic flavonoid which has been used in traditional Chinese medicine as a natural therapeutic agent with a broad spectrum of activities (antioxidant, anticancer, neuroprotective, anti-inflammatory, antiviral and antibacterial). The aim of this study was to develop and validate a rapid and simple ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) method for the determination of quercetin in milk. |
| first_indexed | 2024-12-17T05:34:27Z |
| format | Article |
| id | doaj.art-6239e200e1eb4e37b331d9c753096fb7 |
| institution | Directory Open Access Journal |
| issn | 2450-8608 |
| language | English |
| last_indexed | 2024-12-17T05:34:27Z |
| publishDate | 2019-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj.art-6239e200e1eb4e37b331d9c753096fb72022-12-21T22:01:39ZengSciendoJournal of Veterinary Research2450-86082019-03-01631879110.2478/jvetres-2019-0013jvetres-2019-0013Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic studyGbylik-Sikorska Małgorzata0Gajda Anna1Burmańczuk Artur2Grabowski Tomasz3Posyniak Andrzej4Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100Puławy, PolandDepartment of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100Puławy, PolandDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Life Sciences, 20-033Lublin, PolandPolpharma Biologics, 80-172Gdańsk, PolandDepartment of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100Puławy, PolandIntroduction: Quercetin is a polyphenolic flavonoid which has been used in traditional Chinese medicine as a natural therapeutic agent with a broad spectrum of activities (antioxidant, anticancer, neuroprotective, anti-inflammatory, antiviral and antibacterial). The aim of this study was to develop and validate a rapid and simple ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) method for the determination of quercetin in milk.https://doi.org/10.2478/jvetres-2019-0013quercetinuhplc-ms/msmilkpharmacokinetics |
| spellingShingle | Gbylik-Sikorska Małgorzata Gajda Anna Burmańczuk Artur Grabowski Tomasz Posyniak Andrzej Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study Journal of Veterinary Research quercetin uhplc-ms/ms milk pharmacokinetics |
| title | Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study |
| title_full | Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study |
| title_fullStr | Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study |
| title_full_unstemmed | Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study |
| title_short | Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study |
| title_sort | development of a uhplc ms ms method for the determination of quercetin in milk and its application to a pharmacokinetic study |
| topic | quercetin uhplc-ms/ms milk pharmacokinetics |
| url | https://doi.org/10.2478/jvetres-2019-0013 |
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