Possible Side Effects of Polyphenols and Their Interactions with Medicines
Polyphenols are an important component of plant-derived food with a wide spectrum of beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which are used in the prevention and treatment of many diseases. Unfortunately, a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/6/2536 |
| _version_ | 1797609916200910848 |
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| author | Aleksandra Duda-Chodak Tomasz Tarko |
| author_facet | Aleksandra Duda-Chodak Tomasz Tarko |
| author_sort | Aleksandra Duda-Chodak |
| collection | DOAJ |
| description | Polyphenols are an important component of plant-derived food with a wide spectrum of beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which are used in the prevention and treatment of many diseases. Unfortunately, as with any chemical substance, depending on the conditions, dose, and interactions with the environment, it is possible for polyphenols to also exert harmful effects. This review presents a comprehensive current state of the knowledge on the negative impact of polyphenols on human health, describing the possible side effects of polyphenol intake, especially in the form of supplements. The review begins with a brief overview of the physiological role of polyphenols and their potential use in disease prevention, followed by the harmful effects of polyphenols which are exerted in particular situations. The individual chapters discuss the consequences of polyphenols’ ability to block iron uptake, which in some subpopulations can be harmful, as well as the possible inhibition of digestive enzymes, inhibition of intestinal microbiota, interactions of polyphenolic compounds with drugs, and impact on hormonal balance. Finally, the prooxidative activity of polyphenols as well as their mutagenic, carcinogenic, and genotoxic effects are presented. According to the authors, there is a need to raise public awareness about the possible side effects of polyphenols supplementation, especially in the case of vulnerable subpopulations. |
| first_indexed | 2024-03-11T06:08:16Z |
| format | Article |
| id | doaj.art-6239fc864d434288b1423a0a88510bb4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T06:08:16Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6239fc864d434288b1423a0a88510bb42023-11-17T12:51:42ZengMDPI AGMolecules1420-30492023-03-01286253610.3390/molecules28062536Possible Side Effects of Polyphenols and Their Interactions with MedicinesAleksandra Duda-Chodak0Tomasz Tarko1Department of Fermentation Technology and Microbiology, Faculty of Food Technology, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120 Kraków, PolandDepartment of Fermentation Technology and Microbiology, Faculty of Food Technology, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120 Kraków, PolandPolyphenols are an important component of plant-derived food with a wide spectrum of beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which are used in the prevention and treatment of many diseases. Unfortunately, as with any chemical substance, depending on the conditions, dose, and interactions with the environment, it is possible for polyphenols to also exert harmful effects. This review presents a comprehensive current state of the knowledge on the negative impact of polyphenols on human health, describing the possible side effects of polyphenol intake, especially in the form of supplements. The review begins with a brief overview of the physiological role of polyphenols and their potential use in disease prevention, followed by the harmful effects of polyphenols which are exerted in particular situations. The individual chapters discuss the consequences of polyphenols’ ability to block iron uptake, which in some subpopulations can be harmful, as well as the possible inhibition of digestive enzymes, inhibition of intestinal microbiota, interactions of polyphenolic compounds with drugs, and impact on hormonal balance. Finally, the prooxidative activity of polyphenols as well as their mutagenic, carcinogenic, and genotoxic effects are presented. According to the authors, there is a need to raise public awareness about the possible side effects of polyphenols supplementation, especially in the case of vulnerable subpopulations.https://www.mdpi.com/1420-3049/28/6/2536polyphenolsside effectprooxidant activitytoxicitymutationsDNA damage |
| spellingShingle | Aleksandra Duda-Chodak Tomasz Tarko Possible Side Effects of Polyphenols and Their Interactions with Medicines Molecules polyphenols side effect prooxidant activity toxicity mutations DNA damage |
| title | Possible Side Effects of Polyphenols and Their Interactions with Medicines |
| title_full | Possible Side Effects of Polyphenols and Their Interactions with Medicines |
| title_fullStr | Possible Side Effects of Polyphenols and Their Interactions with Medicines |
| title_full_unstemmed | Possible Side Effects of Polyphenols and Their Interactions with Medicines |
| title_short | Possible Side Effects of Polyphenols and Their Interactions with Medicines |
| title_sort | possible side effects of polyphenols and their interactions with medicines |
| topic | polyphenols side effect prooxidant activity toxicity mutations DNA damage |
| url | https://www.mdpi.com/1420-3049/28/6/2536 |
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