Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review
Abstract Background Varicella zoster virus (VZV) causes varicella and herpes zoster. These vaccine preventable diseases are common globally. Most available data on VZV epidemiology are from industrialised temperate countries and cannot be used to guide decisions on the immunization policy against VZ...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2815-9 |
| _version_ | 1818189177654607872 |
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| author | Hannah Hussey Leila Abdullahi Jamie Collins Rudzani Muloiwa Gregory Hussey Benjamin Kagina |
| author_facet | Hannah Hussey Leila Abdullahi Jamie Collins Rudzani Muloiwa Gregory Hussey Benjamin Kagina |
| author_sort | Hannah Hussey |
| collection | DOAJ |
| description | Abstract Background Varicella zoster virus (VZV) causes varicella and herpes zoster. These vaccine preventable diseases are common globally. Most available data on VZV epidemiology are from industrialised temperate countries and cannot be used to guide decisions on the immunization policy against VZV in Africa. This systematic review aims to review the published data on VZV morbidity and mortality in Africa. Methods All published studies conducted in Africa from 1974 to 2015 were eligible. Eligible studies must have reported any VZV epidemiological measure (incidence, prevalence, hospitalization rate and mortality rate). For inclusion in the review, studies must have used a defined VZV case definition, be it clinical or laboratory-based. Results Twenty articles from 13 African countries were included in the review. Most included studies were cross-sectional, conducted on hospitalized patients, and half of the studies used varying serological methods for diagnosis. VZV seroprevalence was very high among adults. Limited data on VZV seroprevalence in children showed very low seropositivity to anti-VZV antibodies. Co-morbidity with VZV was common. Conclusion There is lack of quality data that could be used to develop VZV control programmes, including vaccination, in Africa. Trial registration PROSPERO 2015: CRD42015026144 . |
| first_indexed | 2024-12-11T23:38:41Z |
| format | Article |
| id | doaj.art-623a324be51c4a52856af17620ab9e79 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-11T23:38:41Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-623a324be51c4a52856af17620ab9e792022-12-22T00:45:47ZengBMCBMC Infectious Diseases1471-23342017-11-0117111110.1186/s12879-017-2815-9Varicella zoster virus-associated morbidity and mortality in Africa – a systematic reviewHannah Hussey0Leila Abdullahi1Jamie Collins2Rudzani Muloiwa3Gregory Hussey4Benjamin Kagina5Institute of Tropical Medicine and International Health, Charité-Universitätsmedizin BerlinVaccines for Africa Initiative, Division of Medical Microbiology & Institute of Infectious Disease and Molecular Medicine, University of Cape TownDepartment of Biostatistics, School of Public Health, Harvard Medical SchoolDepartment of Paediatrics & Child Health, Groote Schuur Hospital, University of Cape TownVaccines for Africa Initiative, Division of Medical Microbiology & Institute of Infectious Disease and Molecular Medicine, University of Cape TownVaccines for Africa Initiative, Division of Medical Microbiology & Institute of Infectious Disease and Molecular Medicine, University of Cape TownAbstract Background Varicella zoster virus (VZV) causes varicella and herpes zoster. These vaccine preventable diseases are common globally. Most available data on VZV epidemiology are from industrialised temperate countries and cannot be used to guide decisions on the immunization policy against VZV in Africa. This systematic review aims to review the published data on VZV morbidity and mortality in Africa. Methods All published studies conducted in Africa from 1974 to 2015 were eligible. Eligible studies must have reported any VZV epidemiological measure (incidence, prevalence, hospitalization rate and mortality rate). For inclusion in the review, studies must have used a defined VZV case definition, be it clinical or laboratory-based. Results Twenty articles from 13 African countries were included in the review. Most included studies were cross-sectional, conducted on hospitalized patients, and half of the studies used varying serological methods for diagnosis. VZV seroprevalence was very high among adults. Limited data on VZV seroprevalence in children showed very low seropositivity to anti-VZV antibodies. Co-morbidity with VZV was common. Conclusion There is lack of quality data that could be used to develop VZV control programmes, including vaccination, in Africa. Trial registration PROSPERO 2015: CRD42015026144 .http://link.springer.com/article/10.1186/s12879-017-2815-9VaricellaZosterShinglesChickenpoxAfricaEpidemiology |
| spellingShingle | Hannah Hussey Leila Abdullahi Jamie Collins Rudzani Muloiwa Gregory Hussey Benjamin Kagina Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review BMC Infectious Diseases Varicella Zoster Shingles Chickenpox Africa Epidemiology |
| title | Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review |
| title_full | Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review |
| title_fullStr | Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review |
| title_full_unstemmed | Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review |
| title_short | Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review |
| title_sort | varicella zoster virus associated morbidity and mortality in africa a systematic review |
| topic | Varicella Zoster Shingles Chickenpox Africa Epidemiology |
| url | http://link.springer.com/article/10.1186/s12879-017-2815-9 |
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