Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

When ribosomes fail to complete normal translation, all cells have mechanisms to ensure degradation of the resulting partial proteins to safeguard proteome integrity. In Escherichia coli and other eubacteria, the tmRNA system rescues stalled ribosomes and adds an ssrA tag or degron to the C-terminus...

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Bibliographic Details
Main Authors: Xue Fei, Tristan A Bell, Sarah R Barkow, Tania A Baker, Robert T Sauer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
AAA+ protease
cryo-EM structures
tmRNA tagging
degradation specificity
recognition complex
intermediate complex
Online Access:https://elifesciences.org/articles/61496

Internet

https://elifesciences.org/articles/61496

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