Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates
When ribosomes fail to complete normal translation, all cells have mechanisms to ensure degradation of the resulting partial proteins to safeguard proteome integrity. In Escherichia coli and other eubacteria, the tmRNA system rescues stalled ribosomes and adds an ssrA tag or degron to the C-terminus...
Main Authors: | Xue Fei, Tristan A Bell, Sarah R Barkow, Tania A Baker, Robert T Sauer |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/61496 |
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