Detection of circulating tumor cells in non-small cell lung cancer
Lung Cancer is the most common cause of cancer related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we pre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00207/full |
| _version_ | 1811269990750355456 |
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| author | Annkathrin eHanssen Sonja eLoges Sonja eLoges Klaus ePantel Harriet eWikman |
| author_facet | Annkathrin eHanssen Sonja eLoges Sonja eLoges Klaus ePantel Harriet eWikman |
| author_sort | Annkathrin eHanssen |
| collection | DOAJ |
| description | Lung Cancer is the most common cause of cancer related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we present and discuss EpCAM-dependent and -independent capture of CTCs in non-small cell lung cancer (NSCLC) and the clinical relevance of CTC detection and characterization. Taking blood samples and analyzing CTCs as liquid biopsy might be a far less invasive diagnostic strategy than biopsies of lung tumors or metastases. Moreover, sequential blood sampling allows to study the dynamic changes of tumor cells during therapy, in particular the development of resistant tumor cell clones. |
| first_indexed | 2024-04-12T21:52:54Z |
| format | Article |
| id | doaj.art-623ac55605654d9284c4e43c9a2faffc |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T21:52:54Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-623ac55605654d9284c4e43c9a2faffc2022-12-22T03:15:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-09-01510.3389/fonc.2015.00207157237Detection of circulating tumor cells in non-small cell lung cancerAnnkathrin eHanssen0Sonja eLoges1Sonja eLoges2Klaus ePantel3Harriet eWikman4Universtiy Medical Center Hamburg EppendorfUniverstiy Medical Center Hamburg EppendorfUniverstiy Medical Center Hamburg EppendorfUniverstiy Medical Center Hamburg EppendorfUniverstiy Medical Center Hamburg EppendorfLung Cancer is the most common cause of cancer related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we present and discuss EpCAM-dependent and -independent capture of CTCs in non-small cell lung cancer (NSCLC) and the clinical relevance of CTC detection and characterization. Taking blood samples and analyzing CTCs as liquid biopsy might be a far less invasive diagnostic strategy than biopsies of lung tumors or metastases. Moreover, sequential blood sampling allows to study the dynamic changes of tumor cells during therapy, in particular the development of resistant tumor cell clones.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00207/fullcirculating tumor cellsCTCNon-small cell lung cancerEpCAMliquid biopsy |
| spellingShingle | Annkathrin eHanssen Sonja eLoges Sonja eLoges Klaus ePantel Harriet eWikman Detection of circulating tumor cells in non-small cell lung cancer Frontiers in Oncology circulating tumor cells CTC Non-small cell lung cancer EpCAM liquid biopsy |
| title | Detection of circulating tumor cells in non-small cell lung cancer |
| title_full | Detection of circulating tumor cells in non-small cell lung cancer |
| title_fullStr | Detection of circulating tumor cells in non-small cell lung cancer |
| title_full_unstemmed | Detection of circulating tumor cells in non-small cell lung cancer |
| title_short | Detection of circulating tumor cells in non-small cell lung cancer |
| title_sort | detection of circulating tumor cells in non small cell lung cancer |
| topic | circulating tumor cells CTC Non-small cell lung cancer EpCAM liquid biopsy |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00207/full |
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