Epidemiological characteristics and pathological changes of primary glomerular diseases.
<h4>Objective</h4>By analyzing the pathological characteristics and clinical data of renal biopsy in our hospital in the past 20 years, to further understand the epidemic characteristics and pathological changes of primary glomerular disease, and to provide regional data for the big data...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0272237 |
| _version_ | 1818495135151816704 |
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| author | Yan Li XiaoYang Yu WenJing Zhang Jia Lv Ping Lan ZhiGang Wang JiPing Sun LiYi Xie WanHong Lu XueLiang Feng Hongli Jiang Yali Zhang |
| author_facet | Yan Li XiaoYang Yu WenJing Zhang Jia Lv Ping Lan ZhiGang Wang JiPing Sun LiYi Xie WanHong Lu XueLiang Feng Hongli Jiang Yali Zhang |
| author_sort | Yan Li |
| collection | DOAJ |
| description | <h4>Objective</h4>By analyzing the pathological characteristics and clinical data of renal biopsy in our hospital in the past 20 years, to further understand the epidemic characteristics and pathological changes of primary glomerular disease, and to provide regional data for the big data of kidney disease in my country.<h4>Methods</h4>A retrospective analysis of 9448 patients with primary glomerular disease who were hospitalized in our hospital from January 1, 2000 to December 31, 2019, aged 18 years or older, and undergoing renal biopsy. Divided every 5 years into a group, a total of 4 groups (first group 2000.1.1-2004.12.31, second groups 2005.1.1-2009.12.31; third groups 2010.1.1-2014.12.31, fourth groups 2015.1.1-2019.12.31).<h4>Results</h4>① There were more males than females, and male: female vs 1.53:1. The proportion of men in the past five years has increased compared with the previous 15 years. ② Mostly middle-aged, with a median age of 41.39 years old. The age is increasing over time. There are differences between the four groups, P <0.001; ③ The most common clinical manifestations are nephrotic syndrome, followed by chronic glomerulonephritis. Occult glomerulonephritis, the proportion of patients with nephrotic syndrome increases over time, first to fourth group (40.08%< 42.64% < 47.08%< 53.69%); ④ The most common pathology type from 2000 to 2009 was mesangial proliferative glomerulonephritis. IgA nephropathy was the most common type from 2010 to 2014, but the proportion of membranous nephropathy increased year by year, and it became the most common pathological type from 2015 to 2019; ⑤ The clinical and pathological manifestations of different genders are different, but there is no statistical difference.<h4>Conclusion</h4>In the past 20 years, the primary glomerular disease is mainly middle-aged. There are more men than women. The most common type of clinical manifestation is nephrotic syndrome. The pathological type is mesangial proliferative glomerulonephritis. Over time, the average age is increasing, and the proportion of patients with renal syndrome is increasing. IgA nephropathy is the most common pathological type from 2010 to 2014, and membranous nephropathy has become the main pathological type in the past 5 years. |
| first_indexed | 2024-12-10T18:16:18Z |
| format | Article |
| id | doaj.art-623e7790e8a44779b258e507a96e1d23 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T18:16:18Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-623e7790e8a44779b258e507a96e1d232022-12-22T01:38:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01178e027223710.1371/journal.pone.0272237Epidemiological characteristics and pathological changes of primary glomerular diseases.Yan LiXiaoYang YuWenJing ZhangJia LvPing LanZhiGang WangJiPing SunLiYi XieWanHong LuXueLiang FengHongli JiangYali Zhang<h4>Objective</h4>By analyzing the pathological characteristics and clinical data of renal biopsy in our hospital in the past 20 years, to further understand the epidemic characteristics and pathological changes of primary glomerular disease, and to provide regional data for the big data of kidney disease in my country.<h4>Methods</h4>A retrospective analysis of 9448 patients with primary glomerular disease who were hospitalized in our hospital from January 1, 2000 to December 31, 2019, aged 18 years or older, and undergoing renal biopsy. Divided every 5 years into a group, a total of 4 groups (first group 2000.1.1-2004.12.31, second groups 2005.1.1-2009.12.31; third groups 2010.1.1-2014.12.31, fourth groups 2015.1.1-2019.12.31).<h4>Results</h4>① There were more males than females, and male: female vs 1.53:1. The proportion of men in the past five years has increased compared with the previous 15 years. ② Mostly middle-aged, with a median age of 41.39 years old. The age is increasing over time. There are differences between the four groups, P <0.001; ③ The most common clinical manifestations are nephrotic syndrome, followed by chronic glomerulonephritis. Occult glomerulonephritis, the proportion of patients with nephrotic syndrome increases over time, first to fourth group (40.08%< 42.64% < 47.08%< 53.69%); ④ The most common pathology type from 2000 to 2009 was mesangial proliferative glomerulonephritis. IgA nephropathy was the most common type from 2010 to 2014, but the proportion of membranous nephropathy increased year by year, and it became the most common pathological type from 2015 to 2019; ⑤ The clinical and pathological manifestations of different genders are different, but there is no statistical difference.<h4>Conclusion</h4>In the past 20 years, the primary glomerular disease is mainly middle-aged. There are more men than women. The most common type of clinical manifestation is nephrotic syndrome. The pathological type is mesangial proliferative glomerulonephritis. Over time, the average age is increasing, and the proportion of patients with renal syndrome is increasing. IgA nephropathy is the most common pathological type from 2010 to 2014, and membranous nephropathy has become the main pathological type in the past 5 years.https://doi.org/10.1371/journal.pone.0272237 |
| spellingShingle | Yan Li XiaoYang Yu WenJing Zhang Jia Lv Ping Lan ZhiGang Wang JiPing Sun LiYi Xie WanHong Lu XueLiang Feng Hongli Jiang Yali Zhang Epidemiological characteristics and pathological changes of primary glomerular diseases. PLoS ONE |
| title | Epidemiological characteristics and pathological changes of primary glomerular diseases. |
| title_full | Epidemiological characteristics and pathological changes of primary glomerular diseases. |
| title_fullStr | Epidemiological characteristics and pathological changes of primary glomerular diseases. |
| title_full_unstemmed | Epidemiological characteristics and pathological changes of primary glomerular diseases. |
| title_short | Epidemiological characteristics and pathological changes of primary glomerular diseases. |
| title_sort | epidemiological characteristics and pathological changes of primary glomerular diseases |
| url | https://doi.org/10.1371/journal.pone.0272237 |
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