Heterologous Boosting With Listeria-Based Recombinant Strains in BCG-Primed Mice Improved Protection Against Pulmonary Mycobacterial Infection

Heterologous Boosting With Listeria-Based Recombinant Strains in BCG-Primed Mice Improved Protection Against Pulmonary Mycobacterial Infection

While Baccillus Calmette-Guerin (BCG) is used worldwide, tuberculosis (TB) is still a global concern due to the poor efficacy of BCG. Novel vaccine candidates are therefore urgently required. In this study, two attenuated recombinant Listeria strains, LMΔ-msv and LIΔ-msv were constructed by deletion...

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Bibliographic Details
Main Authors: Si-Jing Liu, Si-Cheng Tian, Yun-Wen Zhang, Tian Tang, Ju-Mei Zeng, Xiao-Yong Fan, Chuan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
vaccine
Listeria monocytogenes
Listeria ivanovii
multistage
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02036/full

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