Serum amino acid profile in patients with Parkinson's disease.
Amino acids play numerous roles in the central nervous system, serving as neurotransmitters, neuromodulators and regulators of energy metabolism. The free amino acid profile in serum of Parkinson's disease (PD) patients may be influenced by neurodegeneration, mitochondrial dysfunction, malabsor...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5788376?pdf=render |
| _version_ | 1818289882888404992 |
|---|---|
| author | Monika Figura Katarzyna Kuśmierska Ewelina Bucior Stanisław Szlufik Dariusz Koziorowski Zygmunt Jamrozik Piotr Janik |
| author_facet | Monika Figura Katarzyna Kuśmierska Ewelina Bucior Stanisław Szlufik Dariusz Koziorowski Zygmunt Jamrozik Piotr Janik |
| author_sort | Monika Figura |
| collection | DOAJ |
| description | Amino acids play numerous roles in the central nervous system, serving as neurotransmitters, neuromodulators and regulators of energy metabolism. The free amino acid profile in serum of Parkinson's disease (PD) patients may be influenced by neurodegeneration, mitochondrial dysfunction, malabsorption in the gastroenteric tract and received treatment. The aim of our study was the evaluation of the profile of amino acid concentrations against disease progression. We assessed the amino acid profile in the serum of 73 patients divided into groups with early PD, late PD with dyskinesia and late PD without dyskinesia. Serum amino acid analysis was performed by high-pressure liquid chromatography with fluorescence detection. We observed some significant differences amongst the groups with respect to concentrations of alanine, arginine, phenylalanine and threonine, although no significant differences were observed between patients with advanced PD with and without dyskinesia. We conclude that this specific amino acid profile could serve as biochemical marker of PD progression. |
| first_indexed | 2024-12-13T02:19:21Z |
| format | Article |
| id | doaj.art-62413977cd604488837c84857e480bad |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:19:21Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-62413977cd604488837c84857e480bad2022-12-22T00:02:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01131e019167010.1371/journal.pone.0191670Serum amino acid profile in patients with Parkinson's disease.Monika FiguraKatarzyna KuśmierskaEwelina BuciorStanisław SzlufikDariusz KoziorowskiZygmunt JamrozikPiotr JanikAmino acids play numerous roles in the central nervous system, serving as neurotransmitters, neuromodulators and regulators of energy metabolism. The free amino acid profile in serum of Parkinson's disease (PD) patients may be influenced by neurodegeneration, mitochondrial dysfunction, malabsorption in the gastroenteric tract and received treatment. The aim of our study was the evaluation of the profile of amino acid concentrations against disease progression. We assessed the amino acid profile in the serum of 73 patients divided into groups with early PD, late PD with dyskinesia and late PD without dyskinesia. Serum amino acid analysis was performed by high-pressure liquid chromatography with fluorescence detection. We observed some significant differences amongst the groups with respect to concentrations of alanine, arginine, phenylalanine and threonine, although no significant differences were observed between patients with advanced PD with and without dyskinesia. We conclude that this specific amino acid profile could serve as biochemical marker of PD progression.http://europepmc.org/articles/PMC5788376?pdf=render |
| spellingShingle | Monika Figura Katarzyna Kuśmierska Ewelina Bucior Stanisław Szlufik Dariusz Koziorowski Zygmunt Jamrozik Piotr Janik Serum amino acid profile in patients with Parkinson's disease. PLoS ONE |
| title | Serum amino acid profile in patients with Parkinson's disease. |
| title_full | Serum amino acid profile in patients with Parkinson's disease. |
| title_fullStr | Serum amino acid profile in patients with Parkinson's disease. |
| title_full_unstemmed | Serum amino acid profile in patients with Parkinson's disease. |
| title_short | Serum amino acid profile in patients with Parkinson's disease. |
| title_sort | serum amino acid profile in patients with parkinson s disease |
| url | http://europepmc.org/articles/PMC5788376?pdf=render |
| work_keys_str_mv | AT monikafigura serumaminoacidprofileinpatientswithparkinsonsdisease AT katarzynakusmierska serumaminoacidprofileinpatientswithparkinsonsdisease AT ewelinabucior serumaminoacidprofileinpatientswithparkinsonsdisease AT stanisławszlufik serumaminoacidprofileinpatientswithparkinsonsdisease AT dariuszkoziorowski serumaminoacidprofileinpatientswithparkinsonsdisease AT zygmuntjamrozik serumaminoacidprofileinpatientswithparkinsonsdisease AT piotrjanik serumaminoacidprofileinpatientswithparkinsonsdisease |