Microplastics: A threat for developing and repairing organs?
Plastic production has greatly increased in the past decades and has become central to modern human life. Realization is dawning that plastics break down into smaller pieces resulting in micro- or nanoplastics (MNP) that can enter humans directly via the environment. Indeed, MNP have been detected i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-01-01
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| Series: | Cambridge Prisms: Plastics |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2755094X23000196/type/journal_article |
| _version_ | 1797629577832431616 |
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| author | Lars T. Hofstede Gwenda F. Vasse Barbro N. Melgert |
| author_facet | Lars T. Hofstede Gwenda F. Vasse Barbro N. Melgert |
| author_sort | Lars T. Hofstede |
| collection | DOAJ |
| description | Plastic production has greatly increased in the past decades and has become central to modern human life. Realization is dawning that plastics break down into smaller pieces resulting in micro- or nanoplastics (MNP) that can enter humans directly via the environment. Indeed, MNP have been detected in every part of the human body, including the placenta, which is concerning for development. Early developmental stages are crucial for proper growth and genome programming. Environmental disruptors in MNP can have detrimental effects during this critical window as well and can increase the risk of developing disease and dysfunction. In addition, MNP may impact situations in which developmental pathways are reactivated after birth such as during organ repair. Currently, there is no overview of how MNP can impair (human) development and repair. Therefore, we provide an extensive overview of available evidence on MNP impacting developmental and regenerative processes in various organs in humans and rodent models. In addition, we have included the impact of some additives that can leach from these MNP. We conclude that MNP and their additives can have modulating effects on developing and regenerating organs. |
| first_indexed | 2024-03-11T10:56:13Z |
| format | Article |
| id | doaj.art-62417d7afdd84df4be553722772bb45a |
| institution | Directory Open Access Journal |
| issn | 2755-094X |
| language | English |
| last_indexed | 2024-03-11T10:56:13Z |
| publishDate | 2023-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Cambridge Prisms: Plastics |
| spelling | doaj.art-62417d7afdd84df4be553722772bb45a2023-11-13T09:29:15ZengCambridge University PressCambridge Prisms: Plastics2755-094X2023-01-01110.1017/plc.2023.19Microplastics: A threat for developing and repairing organs?Lars T. Hofstede0Gwenda F. Vasse1Barbro N. Melgert2https://orcid.org/0000-0001-7091-907XDepartment of Molecular Pharmacology, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The NetherlandsDepartment of Molecular Pharmacology, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDepartment of Molecular Pharmacology, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsPlastic production has greatly increased in the past decades and has become central to modern human life. Realization is dawning that plastics break down into smaller pieces resulting in micro- or nanoplastics (MNP) that can enter humans directly via the environment. Indeed, MNP have been detected in every part of the human body, including the placenta, which is concerning for development. Early developmental stages are crucial for proper growth and genome programming. Environmental disruptors in MNP can have detrimental effects during this critical window as well and can increase the risk of developing disease and dysfunction. In addition, MNP may impact situations in which developmental pathways are reactivated after birth such as during organ repair. Currently, there is no overview of how MNP can impair (human) development and repair. Therefore, we provide an extensive overview of available evidence on MNP impacting developmental and regenerative processes in various organs in humans and rodent models. In addition, we have included the impact of some additives that can leach from these MNP. We conclude that MNP and their additives can have modulating effects on developing and regenerating organs.https://www.cambridge.org/core/product/identifier/S2755094X23000196/type/journal_articleplasticsadditiveshuman healthbisphenol Aphthalates |
| spellingShingle | Lars T. Hofstede Gwenda F. Vasse Barbro N. Melgert Microplastics: A threat for developing and repairing organs? Cambridge Prisms: Plastics plastics additives human health bisphenol A phthalates |
| title | Microplastics: A threat for developing and repairing organs? |
| title_full | Microplastics: A threat for developing and repairing organs? |
| title_fullStr | Microplastics: A threat for developing and repairing organs? |
| title_full_unstemmed | Microplastics: A threat for developing and repairing organs? |
| title_short | Microplastics: A threat for developing and repairing organs? |
| title_sort | microplastics a threat for developing and repairing organs |
| topic | plastics additives human health bisphenol A phthalates |
| url | https://www.cambridge.org/core/product/identifier/S2755094X23000196/type/journal_article |
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