Rosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in Rats
Introduction: This research investigates the possible potential of Rosa canina (RC) as an immunomodulator in rats and its effects on some biochemical parameters. Methods: In this experiment, 45 male Wistar rats were obtained and divided into three groups (n = 15). These groups received normal saline...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2011-12-01
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| Series: | BioImpacts |
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| Online Access: | http://dx.doi.org/10.5681/bi.2011.031 |
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| author | Saeed Sadigh-Eteghad Hossein Tayefi-Nasrabadi Zahra Aghdam Habib Zarredar Dariush Shanehbandi Leila Khayyat Seyyed-Hamed Seyyed-Piran |
| author_facet | Saeed Sadigh-Eteghad Hossein Tayefi-Nasrabadi Zahra Aghdam Habib Zarredar Dariush Shanehbandi Leila Khayyat Seyyed-Hamed Seyyed-Piran |
| author_sort | Saeed Sadigh-Eteghad |
| collection | DOAJ |
| description | Introduction: This research investigates the possible potential of Rosa canina (RC) as an immunomodulator in rats and its effects on some biochemical parameters. Methods: In this experiment, 45 male Wistar rats were obtained and divided into three groups (n = 15). These groups received normal saline (10 mg/kg), RC fruit extract (250 mg/kg) and RC fruit extract (500 mg/kg) as oral gavages every day for a period of four weeks, respectively. After obtaining blood samples (at the end of each week), differential white blood cell (WBC) counts, phagocyte activity (number), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP) albumin and globulins levels of samples were obtained. The malondialdehyde (MDA) and glutathione (GSH) levels in the serum were determined only in day 28 of study. The radical scavenger activity (RSA) of the RC extract was measured spectrophotometrically. Results: the gamma globulin level, neutrophil and monocyte counts and phagocyte activity increased significantly in comparison with the normal saline group. ALT, AST and ALP had not significantly differences in compared to control group. RC extract significantly increased thiobarbituric acid reactive substances (TBARS) and also decreased GSH levels in comparing to control group in day 28. Conclusion: the data suggest that the RC extract has been used in traditional medicine might have immunomodulatory effects. |
| first_indexed | 2024-12-12T16:12:35Z |
| format | Article |
| id | doaj.art-62419227b5d24ed590dc4ddd41d092fa |
| institution | Directory Open Access Journal |
| issn | 2228-5652 2228-5660 |
| language | English |
| last_indexed | 2024-12-12T16:12:35Z |
| publishDate | 2011-12-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | BioImpacts |
| spelling | doaj.art-62419227b5d24ed590dc4ddd41d092fa2022-12-22T00:19:10ZengTabriz University of Medical SciencesBioImpacts2228-56522228-56602011-12-0114219224Rosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in RatsSaeed Sadigh-EteghadHossein Tayefi-NasrabadiZahra AghdamHabib ZarredarDariush ShanehbandiLeila KhayyatSeyyed-Hamed Seyyed-PiranIntroduction: This research investigates the possible potential of Rosa canina (RC) as an immunomodulator in rats and its effects on some biochemical parameters. Methods: In this experiment, 45 male Wistar rats were obtained and divided into three groups (n = 15). These groups received normal saline (10 mg/kg), RC fruit extract (250 mg/kg) and RC fruit extract (500 mg/kg) as oral gavages every day for a period of four weeks, respectively. After obtaining blood samples (at the end of each week), differential white blood cell (WBC) counts, phagocyte activity (number), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP) albumin and globulins levels of samples were obtained. The malondialdehyde (MDA) and glutathione (GSH) levels in the serum were determined only in day 28 of study. The radical scavenger activity (RSA) of the RC extract was measured spectrophotometrically. Results: the gamma globulin level, neutrophil and monocyte counts and phagocyte activity increased significantly in comparison with the normal saline group. ALT, AST and ALP had not significantly differences in compared to control group. RC extract significantly increased thiobarbituric acid reactive substances (TBARS) and also decreased GSH levels in comparing to control group in day 28. Conclusion: the data suggest that the RC extract has been used in traditional medicine might have immunomodulatory effects.http://dx.doi.org/10.5681/bi.2011.031Rosa caninaImmunological ParametersBiochemical ParametersRats |
| spellingShingle | Saeed Sadigh-Eteghad Hossein Tayefi-Nasrabadi Zahra Aghdam Habib Zarredar Dariush Shanehbandi Leila Khayyat Seyyed-Hamed Seyyed-Piran Rosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in Rats BioImpacts Rosa canina Immunological Parameters Biochemical Parameters Rats |
| title | Rosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in Rats |
| title_full | Rosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in Rats |
| title_fullStr | Rosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in Rats |
| title_full_unstemmed | Rosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in Rats |
| title_short | Rosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in Rats |
| title_sort | rosa canina l fruit hydro alcoholic extract effects on some immunological and biochemical parameters in rats |
| topic | Rosa canina Immunological Parameters Biochemical Parameters Rats |
| url | http://dx.doi.org/10.5681/bi.2011.031 |
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