PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption

PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption

The peroxisome proliferator-activated receptor gamma (PPARγ) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. However, clinical use of TZDs has been limit...

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Bibliographic Details
Main Authors: L.A. Stechschulte, P.J. Czernik, Z.C. Rotter, F.N. Tausif, C.A. Corzo, D.P. Marciano, A. Asteian, J. Zheng, J.B. Bruning, T.M. Kamenecka, C.J. Rosen, P.R. Griffin, B. Lecka-Czernik
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:EBioMedicine
Subjects:
Bone
PPARγ
Insulin sensitizers
Osteoblast
Osteoclast
Osteocyte
Adipocyte
Post-translational modifications
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416302973

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http://www.sciencedirect.com/science/article/pii/S2352396416302973

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