Lysine methyltransferase G9a is an important modulator of trained immunity

Lysine methyltransferase G9a is an important modulator of trained immunity

Abstract Objectives Histone methyltransferase G9a, also known as Euchromatic Histone Lysine Methyltransferase 2 (EHMT2), mediates H3K9 methylation which is associated with transcriptional repression. It possesses immunomodulatory effects and is overexpressed in multiple types of cancer. In this stud...

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Bibliographic Details
Main Authors: Vera P Mourits, Jelmer H vanPuffelen, Boris Novakovic, Mariolina Bruno, Anaísa V Ferreira, Rob JW Arts, Laszlo Groh, Tania O Crișan, Jelle Zwaag, Elisa Jentho, Matthijs Kox, Peter Pickkers, Frank L van deVeerdonk, Sebastian Weis, Egbert Oosterwijk, Sita H Vermeulen, Mihai G Netea, Leo AB Joosten
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
BCG
EHMT2
G9a
inflammation
non‐muscle‐invasive bladder cancer
trained immunity
Online Access:https://doi.org/10.1002/cti2.1253

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