Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels
Stimuli-responsive hydrogel drug delivery systems are designed to release a payload when prompted by an external stimulus. These platforms have become prominent in the field of drug delivery due to their ability to provide spatial and temporal control for drug release. Among the different external t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/8/9/554 |
| _version_ | 1797488109509672960 |
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| author | Tyus J. Yeingst Julien H. Arrizabalaga Daniel J. Hayes |
| author_facet | Tyus J. Yeingst Julien H. Arrizabalaga Daniel J. Hayes |
| author_sort | Tyus J. Yeingst |
| collection | DOAJ |
| description | Stimuli-responsive hydrogel drug delivery systems are designed to release a payload when prompted by an external stimulus. These platforms have become prominent in the field of drug delivery due to their ability to provide spatial and temporal control for drug release. Among the different external triggers that have been used, ultrasound possesses several advantages: it is non-invasive, has deep tissue penetration, and can safely transmit acoustic energy to a localized area. This review summarizes the current state of understanding about ultrasound-responsive hydrogels used for drug delivery. The mechanisms of inducing payload release and activation using ultrasound are examined, along with the latest innovative formulations and hydrogel design strategies. We also report on the most recent applications leveraging ultrasound activation for both cancer treatment and tissue engineering. Finally, the future perspectives offered by ultrasound-sensitive hydrogels are discussed. |
| first_indexed | 2024-03-09T23:57:27Z |
| format | Article |
| id | doaj.art-62428d78943741088836db89242f7ad4 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T23:57:27Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-62428d78943741088836db89242f7ad42023-11-23T16:22:01ZengMDPI AGGels2310-28612022-09-018955410.3390/gels8090554Ultrasound-Induced Drug Release from Stimuli-Responsive HydrogelsTyus J. Yeingst0Julien H. Arrizabalaga1Daniel J. Hayes2Department of Biomedical Engineering, The Pennsylvania State University, University Park, Centre County, PA 16802, USADepartment of Biomedical Engineering, The Pennsylvania State University, University Park, Centre County, PA 16802, USADepartment of Biomedical Engineering, The Pennsylvania State University, University Park, Centre County, PA 16802, USAStimuli-responsive hydrogel drug delivery systems are designed to release a payload when prompted by an external stimulus. These platforms have become prominent in the field of drug delivery due to their ability to provide spatial and temporal control for drug release. Among the different external triggers that have been used, ultrasound possesses several advantages: it is non-invasive, has deep tissue penetration, and can safely transmit acoustic energy to a localized area. This review summarizes the current state of understanding about ultrasound-responsive hydrogels used for drug delivery. The mechanisms of inducing payload release and activation using ultrasound are examined, along with the latest innovative formulations and hydrogel design strategies. We also report on the most recent applications leveraging ultrasound activation for both cancer treatment and tissue engineering. Finally, the future perspectives offered by ultrasound-sensitive hydrogels are discussed.https://www.mdpi.com/2310-2861/8/9/554hydrogelspolymersstimuli-responsiveultrasoundsmart hydrogelsdrug delivery |
| spellingShingle | Tyus J. Yeingst Julien H. Arrizabalaga Daniel J. Hayes Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels Gels hydrogels polymers stimuli-responsive ultrasound smart hydrogels drug delivery |
| title | Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels |
| title_full | Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels |
| title_fullStr | Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels |
| title_full_unstemmed | Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels |
| title_short | Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels |
| title_sort | ultrasound induced drug release from stimuli responsive hydrogels |
| topic | hydrogels polymers stimuli-responsive ultrasound smart hydrogels drug delivery |
| url | https://www.mdpi.com/2310-2861/8/9/554 |
| work_keys_str_mv | AT tyusjyeingst ultrasoundinduceddrugreleasefromstimuliresponsivehydrogels AT julienharrizabalaga ultrasoundinduceddrugreleasefromstimuliresponsivehydrogels AT danieljhayes ultrasoundinduceddrugreleasefromstimuliresponsivehydrogels |