Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and proliferative responses in cardiomyocytes depend on the p...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15552-x |
| _version_ | 1818839336969306112 |
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| author | Megan J. Bywater Deborah L. Burkhart Jasmin Straube Arianna Sabò Vera Pendino James E. Hudson Gregory A. Quaife-Ryan Enzo R. Porrello James Rae Robert G. Parton Theresia R. Kress Bruno Amati Trevor D. Littlewood Gerard I. Evan Catherine H. Wilson |
| author_facet | Megan J. Bywater Deborah L. Burkhart Jasmin Straube Arianna Sabò Vera Pendino James E. Hudson Gregory A. Quaife-Ryan Enzo R. Porrello James Rae Robert G. Parton Theresia R. Kress Bruno Amati Trevor D. Littlewood Gerard I. Evan Catherine H. Wilson |
| author_sort | Megan J. Bywater |
| collection | DOAJ |
| description | Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and proliferative responses in cardiomyocytes depend on the positive transcription elongation factor (P-TEFb). |
| first_indexed | 2024-12-19T03:52:41Z |
| format | Article |
| id | doaj.art-6242a1a22a8f47f48a5d16c07381d895 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T03:52:41Z |
| publishDate | 2020-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6242a1a22a8f47f48a5d16c07381d8952022-12-21T20:36:55ZengNature PortfolioNature Communications2041-17232020-04-0111111710.1038/s41467-020-15552-xReactivation of Myc transcription in the mouse heart unlocks its proliferative capacityMegan J. Bywater0Deborah L. Burkhart1Jasmin Straube2Arianna Sabò3Vera Pendino4James E. Hudson5Gregory A. Quaife-Ryan6Enzo R. Porrello7James Rae8Robert G. Parton9Theresia R. Kress10Bruno Amati11Trevor D. Littlewood12Gerard I. Evan13Catherine H. Wilson14Department of Biochemistry, University of CambridgeDepartment of Biochemistry, University of CambridgeQIMR Berghofer Medical Research InstituteDepartment of Experimental Oncology, European Institute of Oncology (IEO) - IRCCSCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT)QIMR Berghofer Medical Research InstituteQIMR Berghofer Medical Research InstituteMurdoch Children’s Research Institute, The Royal Children’s HospitalInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT)Department of Experimental Oncology, European Institute of Oncology (IEO) - IRCCSDepartment of Biochemistry, University of CambridgeDepartment of Biochemistry, University of CambridgeDepartment of Biochemistry, University of CambridgeLevels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and proliferative responses in cardiomyocytes depend on the positive transcription elongation factor (P-TEFb).https://doi.org/10.1038/s41467-020-15552-x |
| spellingShingle | Megan J. Bywater Deborah L. Burkhart Jasmin Straube Arianna Sabò Vera Pendino James E. Hudson Gregory A. Quaife-Ryan Enzo R. Porrello James Rae Robert G. Parton Theresia R. Kress Bruno Amati Trevor D. Littlewood Gerard I. Evan Catherine H. Wilson Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity Nature Communications |
| title | Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity |
| title_full | Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity |
| title_fullStr | Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity |
| title_full_unstemmed | Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity |
| title_short | Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity |
| title_sort | reactivation of myc transcription in the mouse heart unlocks its proliferative capacity |
| url | https://doi.org/10.1038/s41467-020-15552-x |
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