The variability of responses to growth hormone therapy in children with short stature
Growth hormone (GH) is widely prescribed for children with short stature across a range of growth disorders. We describe the variability of responses seen in conditions approved for GH therapy. Although responses in different growth disorders are satisfactory, evidence is increasing for an unaccepta...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=8;spage=178;epage=184;aulast=Savage |
| _version_ | 1811221217925922816 |
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| author | Martin O Savage Peter Bang |
| author_facet | Martin O Savage Peter Bang |
| author_sort | Martin O Savage |
| collection | DOAJ |
| description | Growth hormone (GH) is widely prescribed for children with short stature across a range of growth disorders. We describe the variability of responses seen in conditions approved for GH therapy. Although responses in different growth disorders are satisfactory, evidence is increasing for an unacceptably high rate of poor or unsatisfactory response (i.e., not leading to significant catch-up growth) in terms of change in height standard deviation score and height velocity. Consequently, there is a need to define a poor response and to prevent or correct it by optimizing treatment regimens. This review discusses the optimal investigation of the child who is a candidate for GH therapy so that a diagnosis-based guide to therapy and dosage can be made. The relevant parameters in the evaluation of growth response are described together with the definitions of a poor response. |
| first_indexed | 2024-04-12T07:55:36Z |
| format | Article |
| id | doaj.art-6243839cb9ba4730b153f2ec605d779f |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-04-12T07:55:36Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-6243839cb9ba4730b153f2ec605d779f2022-12-22T03:41:29ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002012-01-0116817818410.4103/2230-8210.104034The variability of responses to growth hormone therapy in children with short statureMartin O SavagePeter BangGrowth hormone (GH) is widely prescribed for children with short stature across a range of growth disorders. We describe the variability of responses seen in conditions approved for GH therapy. Although responses in different growth disorders are satisfactory, evidence is increasing for an unacceptably high rate of poor or unsatisfactory response (i.e., not leading to significant catch-up growth) in terms of change in height standard deviation score and height velocity. Consequently, there is a need to define a poor response and to prevent or correct it by optimizing treatment regimens. This review discusses the optimal investigation of the child who is a candidate for GH therapy so that a diagnosis-based guide to therapy and dosage can be made. The relevant parameters in the evaluation of growth response are described together with the definitions of a poor response.http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=8;spage=178;epage=184;aulast=SavageGrowthgrowth hormone therapygrowth responseheightrecombinant human insulin-like growth-factor-1 therapyshort stature |
| spellingShingle | Martin O Savage Peter Bang The variability of responses to growth hormone therapy in children with short stature Indian Journal of Endocrinology and Metabolism Growth growth hormone therapy growth response height recombinant human insulin-like growth-factor-1 therapy short stature |
| title | The variability of responses to growth hormone therapy in children with short stature |
| title_full | The variability of responses to growth hormone therapy in children with short stature |
| title_fullStr | The variability of responses to growth hormone therapy in children with short stature |
| title_full_unstemmed | The variability of responses to growth hormone therapy in children with short stature |
| title_short | The variability of responses to growth hormone therapy in children with short stature |
| title_sort | variability of responses to growth hormone therapy in children with short stature |
| topic | Growth growth hormone therapy growth response height recombinant human insulin-like growth-factor-1 therapy short stature |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=8;spage=178;epage=184;aulast=Savage |
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