Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Coupling of endoplasmic reticulum (ER) stress to dimerisation-dependent activation of the UPR transducer IRE1 is incompletely understood. Whilst the luminal co-chaperone ERdj4 promotes a complex between the Hsp70 BiP and IRE1’s stress-sensing luminal domain (IRE1LD) that favours the latter’s monomer...

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Bibliographic Details
Main Authors: Niko Amin-Wetzel, Lisa Neidhardt, Yahui Yan, Matthias P Mayer, David Ron
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
IRE1
BiP/Grp78
endoplasmic reticulum (ER)
unfolded protein response (UPR)
ERdj4/DNAJB9
Chinese Hamster Ovary (CHO) cells
Online Access:https://elifesciences.org/articles/50793

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