Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia

Abstract Background More effective targeted therapy and new combination regimens are needed for Acute myeloid leukemia (AML), owing to the unsatisfactory long-term prognosis of the disease. Here, we investigated the synergistic effect and the mechanism of a histone deacetylase inhibitor, Chidamide i...

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Bibliographic Details
Main Authors: Siyu Gu, Yue Hou, Katarina Dovat, Sinisa Dovat, Chunhua Song, Zheng Ge
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Experimental Hematology & Oncology
Subjects:
AML
HDACi
Cladribine
c-Myc
RCC1
Online Access:https://doi.org/10.1186/s40164-023-00383-5

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