Retinoic Acid Signaling Modulates Recipient Gut Barrier Integrity and Microbiota After Allogeneic Hematopoietic Stem Cell Transplantation in Mice

Retinoic Acid Signaling Modulates Recipient Gut Barrier Integrity and Microbiota After Allogeneic Hematopoietic Stem Cell Transplantation in Mice

Graft-versus-host disease (GVHD) remains a major complication after allogeneic hematopoietic stem cell transplantation (HSCT). An impaired intestinal epithelial barrier is an important component of GVHD pathogenesis. However, contributing host factors that modulate mucosal barrier integrity during G...

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Bibliographic Details
Main Authors: Pan Pan, Samantha N. Atkinson, Brian Taylor, Haojie Zhu, Dian Zhou, Philip Flejsierowicz, Li-Shu Wang, Matthew Morse, Chen Liu, Ian L. Gunsolus, Xiao Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
retinoic acid
intestinal barrier
gut microbiota
vitamin A
graft-versus-host disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.749002/full

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