Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines
A great deal of modern catalytic research orients around the architecturally designed bio-engineered catalysts. In this context, we have adorned Cu NPs over pectin encapsulated Fe3O4 NPs. The Cu NPs were generated following a biogenic green pathway over the core-shell type nanocomposite promoted by...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S187853522100321X |
| _version_ | 1818606744168824832 |
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| author | Weisong Xue Guohua Yang Bikash Karmakar Yi Gao |
| author_facet | Weisong Xue Guohua Yang Bikash Karmakar Yi Gao |
| author_sort | Weisong Xue |
| collection | DOAJ |
| description | A great deal of modern catalytic research orients around the architecturally designed bio-engineered catalysts. In this context, we have adorned Cu NPs over pectin encapsulated Fe3O4 NPs. The Cu NPs were generated following a biogenic green pathway over the core-shell type nanocomposite promoted by Mentha Pulegium flower extract as natural reducing/stabilizing agent. The as-synthesized nanocomposite was meticulously characterized by using a wide range of physicochemical techniques like FT-IR, FESEM, TEM, EDX, elemental mapping, VSM, XRD and ICP-OES analysis. The catalyst was explored in the synthesis of diversely substituted 1H-tetrazoles via three component coupling reaction (MCR), under solvent-less conditions affording high to excellent yields. Heterogeneity of the catalyst was measured through its excellent reusability, hot-filtration test and leaching study. The nanocomposite was also explored biologically in the anticancer assays. In the cytotoxicity and anti-human colon carcinoma studies, the nanocomposite was treated to colorectal adenocarcinoma (HT-29) cell line following MTT assay. The cell viability of malignant colon cell line reduced dose-dependently in the presence of Cu/Pectin@Fe3O4 nanocomposite. IC50 values of the nanocomposite were observed to be 1450.84 μg/mL against HT-29 cell line. The outstanding results showed by the developed nanocomposite, could be highly promising in cancer management in near future. |
| first_indexed | 2024-12-16T14:15:43Z |
| format | Article |
| id | doaj.art-624a5be5f11b49359a2bc72534dda8fa |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-16T14:15:43Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-624a5be5f11b49359a2bc72534dda8fa2022-12-21T22:28:37ZengElsevierArabian Journal of Chemistry1878-53522021-09-01149103306Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell linesWeisong Xue0Guohua Yang1Bikash Karmakar2Yi Gao3Department of General Surgery, The South Brother of Fujian Province Hospital, Fuzhou, Fujian Province 350000, China; General Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province 510280, ChinaDepartment of General Surgery, The South Brother of Fujian Province Hospital, Fuzhou, Fujian Province 350000, China; Corresponding author.Department of Chemistry, Gobardanga Hindu College, 24 Parganas (North), IndiaGeneral Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province 510280, ChinaA great deal of modern catalytic research orients around the architecturally designed bio-engineered catalysts. In this context, we have adorned Cu NPs over pectin encapsulated Fe3O4 NPs. The Cu NPs were generated following a biogenic green pathway over the core-shell type nanocomposite promoted by Mentha Pulegium flower extract as natural reducing/stabilizing agent. The as-synthesized nanocomposite was meticulously characterized by using a wide range of physicochemical techniques like FT-IR, FESEM, TEM, EDX, elemental mapping, VSM, XRD and ICP-OES analysis. The catalyst was explored in the synthesis of diversely substituted 1H-tetrazoles via three component coupling reaction (MCR), under solvent-less conditions affording high to excellent yields. Heterogeneity of the catalyst was measured through its excellent reusability, hot-filtration test and leaching study. The nanocomposite was also explored biologically in the anticancer assays. In the cytotoxicity and anti-human colon carcinoma studies, the nanocomposite was treated to colorectal adenocarcinoma (HT-29) cell line following MTT assay. The cell viability of malignant colon cell line reduced dose-dependently in the presence of Cu/Pectin@Fe3O4 nanocomposite. IC50 values of the nanocomposite were observed to be 1450.84 μg/mL against HT-29 cell line. The outstanding results showed by the developed nanocomposite, could be highly promising in cancer management in near future.http://www.sciencedirect.com/science/article/pii/S187853522100321XPectinCu NP1-substituted tetrazolesReusableCytotoxicityAnti-colon cancer |
| spellingShingle | Weisong Xue Guohua Yang Bikash Karmakar Yi Gao Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines Arabian Journal of Chemistry Pectin Cu NP 1-substituted tetrazoles Reusable Cytotoxicity Anti-colon cancer |
| title | Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines |
| title_full | Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines |
| title_fullStr | Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines |
| title_full_unstemmed | Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines |
| title_short | Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines |
| title_sort | sustainable synthesis of cu nps decorated on pectin modified fe3o4 nanocomposite catalytic synthesis of 1 substituted 1h tetrazoles and in vitro studies on its cytotoxicity and anti colorectal adenocarcinoma effects on ht 29 cell lines |
| topic | Pectin Cu NP 1-substituted tetrazoles Reusable Cytotoxicity Anti-colon cancer |
| url | http://www.sciencedirect.com/science/article/pii/S187853522100321X |
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