Expression of Non-T Cell Activation Linker (NTAL) in Jurkat Cells Negatively Regulates TCR Signaling: Potential Role in Rheumatoid Arthritis

Expression of Non-T Cell Activation Linker (NTAL) in Jurkat Cells Negatively Regulates TCR Signaling: Potential Role in Rheumatoid Arthritis

T lymphocytes are key players in adaptive immune responses through the recognition of peptide antigens through the T Cell Receptor (TCR). After TCR engagement, a signaling cascade is activated, leading to T cell activation, proliferation, and differentiation into effector cells. Delicate control of...

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Bibliographic Details
Main Authors: Isaac Narbona-Sánchez, Alba Pérez-Linaza, Isabel Serrano-García, Inmaculada Vico-Barranco, Luis M. Fernández-Aguilar, José L. Poveda-Díaz, María J. Sánchez del Pino, Fermín Medina-Varo, Mikel M. Arbulo-Echevarria, Enrique Aguado
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
NTAL
LAT2
LAB
rheumatoid arthritis
TCR
signaling
Online Access:https://www.mdpi.com/1422-0067/24/5/4574

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