Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease
Copper (Ⅱ) theophylline [Cu(THP)2(H2O)4] complex in nanoscale has synthesized by ultrasonic sonication method. This method was used in the development of smaller, dispersed, and unaggregated nanoparticles (NPs). The structure of nanocomplex was described and suggested by the molar conductance, Fouri...
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| Format: | Article |
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Tsinghua University Press
2021-12-01
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| Series: | Nano Biomedicine and Engineering |
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| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v13i4.p364-371 |
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| author | Zainab Sabri Abbas Ahmad Hussein Ismail Hassanain Kamil Al-Bairmani Ahmed Mahdi Rheima Ameer Radhi Sultan Srwa Hashim Mohammed |
| author_facet | Zainab Sabri Abbas Ahmad Hussein Ismail Hassanain Kamil Al-Bairmani Ahmed Mahdi Rheima Ameer Radhi Sultan Srwa Hashim Mohammed |
| author_sort | Zainab Sabri Abbas |
| collection | DOAJ |
| description | Copper (Ⅱ) theophylline [Cu(THP)2(H2O)4] complex in nanoscale has synthesized by ultrasonic sonication method. This method was used in the development of smaller, dispersed, and unaggregated nanoparticles (NPs). The structure of nanocomplex was described and suggested by the molar conductance, Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), solubility, atomic fire absorption, and C.H.N. elemental analysis as octahedral geometry. The size and morphology of nanocomplex measured by transmission electron microscopy (TEM) were 20 nm. The nanocomplex was studied on phosphodiesterase enzyme activity in human serum of Iraqi patient?s asthma disease. The results showed a highly significant (p < 0.01) increase in the serum levels of phosphodiesterase enzyme activity in asthma patients (mean = 14.939 ± 3.021 ng/mL) compared with a control group (mean = 9.974 ± 2.032 ng/mL). The result also showed a highly significant (p < 0.01) decrease in the serum levels of phosphodiesterase activity in patients of asthma disease with theophylline (mean = 11.253 ± 2.479 ng/mL) compared to serum patients without nano and control groups. It is vital that the result showed a highly significant (p < 0.01) decrease in the serum levels of phosphodiesterase activity in patients of asthma disease with copper nano complex (mean = 9.563 ± 2.082 ng/mL) compared in patients of asthma disease with and without theophylline. As for comparing asthma disease with copper nano complex and control group, the result showed there was no significant effect (p > 0.05). |
| first_indexed | 2024-03-11T21:43:37Z |
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| id | doaj.art-624b90fcc1a141a19a73b4f0c9bad2f9 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:43:37Z |
| publishDate | 2021-12-01 |
| publisher | Tsinghua University Press |
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| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-624b90fcc1a141a19a73b4f0c9bad2f92023-09-26T11:05:06ZengTsinghua University PressNano Biomedicine and Engineering2150-55782021-12-0113436437110.5101/nbe.v13i4.p364-371Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma DiseaseZainab Sabri Abbas0Ahmad Hussein Ismail1Hassanain Kamil Al-Bairmani2Ahmed Mahdi Rheima3Ameer Radhi Sultan4Srwa Hashim Mohammed5Kut University College, Dentistry Department, Al-Kut, Wasit, Iraq, 52001Mustansiriyah University, College of Science, Department of Chemistry. IraqMustansiriyah University, College of Science, Department of Chemistry. IraqWasit University, College of Science, Department of Chemistry, Kut, IraqDepartment of Chemistry Lab, Al-lmamine Al-Kadhumain Medical City Hospital, Baghdad, IraqGarmian University, College of Education, Department of Chemistry. Kalar, IraqCopper (Ⅱ) theophylline [Cu(THP)2(H2O)4] complex in nanoscale has synthesized by ultrasonic sonication method. This method was used in the development of smaller, dispersed, and unaggregated nanoparticles (NPs). The structure of nanocomplex was described and suggested by the molar conductance, Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), solubility, atomic fire absorption, and C.H.N. elemental analysis as octahedral geometry. The size and morphology of nanocomplex measured by transmission electron microscopy (TEM) were 20 nm. The nanocomplex was studied on phosphodiesterase enzyme activity in human serum of Iraqi patient?s asthma disease. The results showed a highly significant (p < 0.01) increase in the serum levels of phosphodiesterase enzyme activity in asthma patients (mean = 14.939 ± 3.021 ng/mL) compared with a control group (mean = 9.974 ± 2.032 ng/mL). The result also showed a highly significant (p < 0.01) decrease in the serum levels of phosphodiesterase activity in patients of asthma disease with theophylline (mean = 11.253 ± 2.479 ng/mL) compared to serum patients without nano and control groups. It is vital that the result showed a highly significant (p < 0.01) decrease in the serum levels of phosphodiesterase activity in patients of asthma disease with copper nano complex (mean = 9.563 ± 2.082 ng/mL) compared in patients of asthma disease with and without theophylline. As for comparing asthma disease with copper nano complex and control group, the result showed there was no significant effect (p > 0.05).https://www.sciopen.com/article/10.5101/nbe.v13i4.p364-371nanocomplexasthmaphosphodiesterase (pde)theophyllineultrasonic sonication method |
| spellingShingle | Zainab Sabri Abbas Ahmad Hussein Ismail Hassanain Kamil Al-Bairmani Ahmed Mahdi Rheima Ameer Radhi Sultan Srwa Hashim Mohammed Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease Nano Biomedicine and Engineering nanocomplex asthma phosphodiesterase (pde) theophylline ultrasonic sonication method |
| title | Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease |
| title_full | Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease |
| title_fullStr | Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease |
| title_full_unstemmed | Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease |
| title_short | Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease |
| title_sort | inhibition effect ofcopper ii theophylline nanocomplex on phosphodiesterase pde enzyme activity in human serum of iraqi patients with asthma disease |
| topic | nanocomplex asthma phosphodiesterase (pde) theophylline ultrasonic sonication method |
| url | https://www.sciopen.com/article/10.5101/nbe.v13i4.p364-371 |
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