Copper‐Zinc Bimetallic Single‐Atom Catalysts with Localized Surface Plasmon Resonance‐Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound‐Healing
Abstract Nanomaterials with photothermal combined chemodynamic therapy (PTT‐CDT) have attracted the attention of researchers owing to their excellent synergistic therapeutic effects on tumors. Thus, the preparation of multifunctional materials with higher photothermal conversion efficiency and catal...
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202207342 |
| _version_ | 1797797000588034048 |
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| author | Lidan Liu Haifeng Zhang Shun Xing Yu Zhang Li Shangguan Chao Wei Feng Peng Xuanyong Liu |
| author_facet | Lidan Liu Haifeng Zhang Shun Xing Yu Zhang Li Shangguan Chao Wei Feng Peng Xuanyong Liu |
| author_sort | Lidan Liu |
| collection | DOAJ |
| description | Abstract Nanomaterials with photothermal combined chemodynamic therapy (PTT‐CDT) have attracted the attention of researchers owing to their excellent synergistic therapeutic effects on tumors. Thus, the preparation of multifunctional materials with higher photothermal conversion efficiency and catalytic activity can achieve better synergistic therapeutic effects for melanoma. In this study, a Cu–Zn bimetallic single‐atom (Cu/PMCS) is constructed with augmented photothermal effect and catalytic activity due to the localized surface plasmon resonance (LSPR) effect. Density functional theory calculations confirmed that the enhanced photothermal effect of Cu/PMCS is due to the appearance of a new d‐orbital transition with strong spin‐orbit coupling and the induced LSPR. Additionally, Cu/PMCS exhibited increased catalytic activity in the Fenton‐like reaction and glutathione depletion capacity, further enhanced by increased temperature and LSPR. Consequently, Cu/PMCS induced better synergistic anti‐melanoma effects via PTT‐CDT than PMCS in vitro and in vivo. Furthermore, compared with PMCS, Cu/PMCS killed bacteria more quickly and effectively, thus facilitating wound healing owing to the enhanced photothermal effect and slow release of Cu2+. Cu/PMCS promoted cell migration and angiogenesis and upregulated the expression of related genes to accelerate wound healing. Cu/PMCS has potential applications in treating melanoma and repairing wounds with its antitumor, antibacterial, and wound‐healing properties. |
| first_indexed | 2024-03-13T03:41:30Z |
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| id | doaj.art-624bbc7c083e483baa844b26f8631224 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-13T03:41:30Z |
| publishDate | 2023-06-01 |
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| series | Advanced Science |
| spelling | doaj.art-624bbc7c083e483baa844b26f86312242023-06-23T07:34:34ZengWileyAdvanced Science2198-38442023-06-011018n/an/a10.1002/advs.202207342Copper‐Zinc Bimetallic Single‐Atom Catalysts with Localized Surface Plasmon Resonance‐Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound‐HealingLidan Liu0Haifeng Zhang1Shun Xing2Yu Zhang3Li Shangguan4Chao Wei5Feng Peng6Xuanyong Liu7State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaMedical Research Institute Department of Orthopedics Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou 510080 ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaMedical Research Institute Department of Orthopedics Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou 510080 ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaAbstract Nanomaterials with photothermal combined chemodynamic therapy (PTT‐CDT) have attracted the attention of researchers owing to their excellent synergistic therapeutic effects on tumors. Thus, the preparation of multifunctional materials with higher photothermal conversion efficiency and catalytic activity can achieve better synergistic therapeutic effects for melanoma. In this study, a Cu–Zn bimetallic single‐atom (Cu/PMCS) is constructed with augmented photothermal effect and catalytic activity due to the localized surface plasmon resonance (LSPR) effect. Density functional theory calculations confirmed that the enhanced photothermal effect of Cu/PMCS is due to the appearance of a new d‐orbital transition with strong spin‐orbit coupling and the induced LSPR. Additionally, Cu/PMCS exhibited increased catalytic activity in the Fenton‐like reaction and glutathione depletion capacity, further enhanced by increased temperature and LSPR. Consequently, Cu/PMCS induced better synergistic anti‐melanoma effects via PTT‐CDT than PMCS in vitro and in vivo. Furthermore, compared with PMCS, Cu/PMCS killed bacteria more quickly and effectively, thus facilitating wound healing owing to the enhanced photothermal effect and slow release of Cu2+. Cu/PMCS promoted cell migration and angiogenesis and upregulated the expression of related genes to accelerate wound healing. Cu/PMCS has potential applications in treating melanoma and repairing wounds with its antitumor, antibacterial, and wound‐healing properties.https://doi.org/10.1002/advs.202207342bimetallic single‐atomlocalized surface plasmon resonancemelanoma therapyphotothermal combined chemodynamic therapywound healing |
| spellingShingle | Lidan Liu Haifeng Zhang Shun Xing Yu Zhang Li Shangguan Chao Wei Feng Peng Xuanyong Liu Copper‐Zinc Bimetallic Single‐Atom Catalysts with Localized Surface Plasmon Resonance‐Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound‐Healing Advanced Science bimetallic single‐atom localized surface plasmon resonance melanoma therapy photothermal combined chemodynamic therapy wound healing |
| title | Copper‐Zinc Bimetallic Single‐Atom Catalysts with Localized Surface Plasmon Resonance‐Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound‐Healing |
| title_full | Copper‐Zinc Bimetallic Single‐Atom Catalysts with Localized Surface Plasmon Resonance‐Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound‐Healing |
| title_fullStr | Copper‐Zinc Bimetallic Single‐Atom Catalysts with Localized Surface Plasmon Resonance‐Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound‐Healing |
| title_full_unstemmed | Copper‐Zinc Bimetallic Single‐Atom Catalysts with Localized Surface Plasmon Resonance‐Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound‐Healing |
| title_short | Copper‐Zinc Bimetallic Single‐Atom Catalysts with Localized Surface Plasmon Resonance‐Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound‐Healing |
| title_sort | copper zinc bimetallic single atom catalysts with localized surface plasmon resonance enhanced photothermal effect and catalytic activity for melanoma treatment and wound healing |
| topic | bimetallic single‐atom localized surface plasmon resonance melanoma therapy photothermal combined chemodynamic therapy wound healing |
| url | https://doi.org/10.1002/advs.202207342 |
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