Serum Uric Acid Relation for Hearing Threshold Shift
Objectives The effects of serum uric acid (UA) level on a variety of diseases were found from experimental and observational studies via oxidative stress and anti-oxidants. However, research on the association of UA and hearing thresholds is relatively sparse. We investigated this issue in the U.S....
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| Format: | Article |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2017-06-01
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| Series: | Clinical and Experimental Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.e-ceo.org/upload/pdf/ceo-2016-00346.pdf |
| _version_ | 1818231454351491072 |
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| author | Hui-Fang Yang Tung-Wei Kao Tao-Chun Peng Yu-Shan Sun Fang-Yih Liaw Chung-Ching Wang Ju-Ting Hsueh Wei-Liang Chen |
| author_facet | Hui-Fang Yang Tung-Wei Kao Tao-Chun Peng Yu-Shan Sun Fang-Yih Liaw Chung-Ching Wang Ju-Ting Hsueh Wei-Liang Chen |
| author_sort | Hui-Fang Yang |
| collection | DOAJ |
| description | Objectives The effects of serum uric acid (UA) level on a variety of diseases were found from experimental and observational studies via oxidative stress and anti-oxidants. However, research on the association of UA and hearing thresholds is relatively sparse. We investigated this issue in the U.S. general population to evaluate the relationship of serum UA levels and pure tone threshold of hearing. Methods Forty four thousand eighty four eligible participants aged 20 to 69 years who have serum UA data and received Audiometry Examination Component were enrolled from the National Health and Nutrition Examination Survey 1999–2004. Hearing thresholds (dB) as a pure tone average at low frequencies (0.5, 1, 2 kHz) and at high frequencies (3, 4, 6, and 8 kHz) were computed. Multivariate linear regression models and tertile-based analysis with an extended-model approach for covariates adjustment were used to assess the correlation between serum UA level and hearing thresholds. Results In the adjusted mode of tertile-based analysis, the regression coefficients elucidated as the change of log-transformed mean hearing thresholds upon comparing participants in the highest tertile of serum UA to those in the lowest tertile were –0.067 (P=0.023) in high frequency and –0.058 (P=0.054) in low frequency. After adjusting for multiple pertinent covariates, inverse association between tertiles of serum UA and hearing thresholds remained essentially unchanged. The negative trends between serum UA and hearing thresholds were statistically significant (P for trends <0.05) in tertile-based multiple linear regressions. Conclusion Individuals with elevated UA levels independently were found to be inversely associated with hearing thresholds for pure tone audiometry in a nationally representative sample of U.S. adults. |
| first_indexed | 2024-12-12T10:50:39Z |
| format | Article |
| id | doaj.art-624c24b5fba043dd951f736a1a72da56 |
| institution | Directory Open Access Journal |
| issn | 1976-8710 2005-0720 |
| language | English |
| last_indexed | 2024-12-12T10:50:39Z |
| publishDate | 2017-06-01 |
| publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
| record_format | Article |
| series | Clinical and Experimental Otorhinolaryngology |
| spelling | doaj.art-624c24b5fba043dd951f736a1a72da562022-12-22T00:26:47ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202017-06-0110214314710.21053/ceo.2016.00346517Serum Uric Acid Relation for Hearing Threshold ShiftHui-Fang Yang0Tung-Wei Kao1Tao-Chun Peng2Yu-Shan Sun3Fang-Yih Liaw4Chung-Ching Wang5Ju-Ting Hsueh6Wei-Liang Chen7 Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, TaiwanObjectives The effects of serum uric acid (UA) level on a variety of diseases were found from experimental and observational studies via oxidative stress and anti-oxidants. However, research on the association of UA and hearing thresholds is relatively sparse. We investigated this issue in the U.S. general population to evaluate the relationship of serum UA levels and pure tone threshold of hearing. Methods Forty four thousand eighty four eligible participants aged 20 to 69 years who have serum UA data and received Audiometry Examination Component were enrolled from the National Health and Nutrition Examination Survey 1999–2004. Hearing thresholds (dB) as a pure tone average at low frequencies (0.5, 1, 2 kHz) and at high frequencies (3, 4, 6, and 8 kHz) were computed. Multivariate linear regression models and tertile-based analysis with an extended-model approach for covariates adjustment were used to assess the correlation between serum UA level and hearing thresholds. Results In the adjusted mode of tertile-based analysis, the regression coefficients elucidated as the change of log-transformed mean hearing thresholds upon comparing participants in the highest tertile of serum UA to those in the lowest tertile were –0.067 (P=0.023) in high frequency and –0.058 (P=0.054) in low frequency. After adjusting for multiple pertinent covariates, inverse association between tertiles of serum UA and hearing thresholds remained essentially unchanged. The negative trends between serum UA and hearing thresholds were statistically significant (P for trends <0.05) in tertile-based multiple linear regressions. Conclusion Individuals with elevated UA levels independently were found to be inversely associated with hearing thresholds for pure tone audiometry in a nationally representative sample of U.S. adults.http://www.e-ceo.org/upload/pdf/ceo-2016-00346.pdfUric AcidHearingAntioxidantsNeuroprotection |
| spellingShingle | Hui-Fang Yang Tung-Wei Kao Tao-Chun Peng Yu-Shan Sun Fang-Yih Liaw Chung-Ching Wang Ju-Ting Hsueh Wei-Liang Chen Serum Uric Acid Relation for Hearing Threshold Shift Clinical and Experimental Otorhinolaryngology Uric Acid Hearing Antioxidants Neuroprotection |
| title | Serum Uric Acid Relation for Hearing Threshold Shift |
| title_full | Serum Uric Acid Relation for Hearing Threshold Shift |
| title_fullStr | Serum Uric Acid Relation for Hearing Threshold Shift |
| title_full_unstemmed | Serum Uric Acid Relation for Hearing Threshold Shift |
| title_short | Serum Uric Acid Relation for Hearing Threshold Shift |
| title_sort | serum uric acid relation for hearing threshold shift |
| topic | Uric Acid Hearing Antioxidants Neuroprotection |
| url | http://www.e-ceo.org/upload/pdf/ceo-2016-00346.pdf |
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