Identification of Potential p38γ Inhibitors via In Silico Screening, In Vitro Bioassay and Molecular Dynamics Simulation Studies

Identification of Potential p38γ Inhibitors via In Silico Screening, In Vitro Bioassay and Molecular Dynamics Simulation Studies

Protein kinase p38γ is an attractive target against cancer because it plays a pivotal role in cancer cell proliferation by phosphorylating the retinoblastoma tumour suppressor protein. Therefore, inhibition of p38γ with active small molecules represents an attractive alternative for developing anti-...

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Bibliographic Details
Main Authors: Zixuan Cheng, Mrinal Bhave, Siaw San Hwang, Taufiq Rahman, Xavier Wezen Chee
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
p38γ
QSAR modelling
virtual screening
molecular dynamic simulations
binding interaction
Online Access:https://www.mdpi.com/1422-0067/24/8/7360

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