Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease Severity
The purpose of this study was to explore the relationships between heart rate variability (HRV) and various phenotypic measures that relate to health and functional status in chronic obstructive pulmonary disease (COPD), and secondly, to demonstrate the feasibility of ascertaining HRV via a chest-wo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/22/6/2264 |
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| author | Seon-Cheol Park Narongkorn Saiphoklang Donghyun Jung David Gomez Jonathan E. Phillips Brett A. Dolezal Donald P. Tashkin Igor Barjaktarevic Christopher B. Cooper |
| author_facet | Seon-Cheol Park Narongkorn Saiphoklang Donghyun Jung David Gomez Jonathan E. Phillips Brett A. Dolezal Donald P. Tashkin Igor Barjaktarevic Christopher B. Cooper |
| author_sort | Seon-Cheol Park |
| collection | DOAJ |
| description | The purpose of this study was to explore the relationships between heart rate variability (HRV) and various phenotypic measures that relate to health and functional status in chronic obstructive pulmonary disease (COPD), and secondly, to demonstrate the feasibility of ascertaining HRV via a chest-worn wearable biosensor in COPD patients. HRV analysis was performed using SDNN (standard deviation of the mean of all normal R-R intervals), low frequency (LF), high frequency (HF), and LF/HF ratio. We evaluated the associations between HRV and COPD severity, class of bronchodilator therapy prescribed, and patient reported outcomes. Seventy-nine participants with COPD were enrolled. There were no differences in SDNN, HF, and LF/HF ratio according to COPD severity. The SDNN in participants treated with concurrent beta-agonists and muscarinic antagonists was lower than that in other participants after adjusting heart rate (beta coefficient −3.980, <i>p</i> = 0.019). The SDNN was positively correlated with Veterans Specific Activity Questionnaire (VSAQ) score (<i>r</i> = 0.308, <i>p</i> = 0.006) and handgrip strength (<i>r</i> = 0.285, <i>p</i> = 0.011), and negatively correlated with dyspnea by modified Medical Research Council (mMRC) questionnaire (<i>r</i> = −0.234, <i>p</i> = 0.039), health status by Saint George’s Respiratory Questionnaire (SGRQ) (<i>r</i> = −0.298, <i>p</i> = 0.008), symptoms by COPD Assessment Test (CAT) (<i>r</i> = −0.280, <i>p</i> = 0.012), and BODE index (<i>r</i> = −0.269, <i>p</i> = 0.020). When measured by a chest-worn wearable device, reduced HRV was observed in COPD participants receiving inhaled beta-sympathomimetic agonist and muscarinic antagonists. HRV was also correlated with various health status and performance measures. |
| first_indexed | 2024-03-09T12:40:50Z |
| format | Article |
| id | doaj.art-624e0d8c6c80473cbe9f0acf0d40cc4a |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-09T12:40:50Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Sensors |
| spelling | doaj.art-624e0d8c6c80473cbe9f0acf0d40cc4a2023-11-30T22:18:30ZengMDPI AGSensors1424-82202022-03-01226226410.3390/s22062264Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease SeveritySeon-Cheol Park0Narongkorn Saiphoklang1Donghyun Jung2David Gomez3Jonathan E. Phillips4Brett A. Dolezal5Donald P. Tashkin6Igor Barjaktarevic7Christopher B. Cooper8Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USAUCLA Airways and Exercise Physiology Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USAUCLA Airways and Exercise Physiology Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USAInflammation Discovery Research, Amgen, Thousand Oaks, CA 91320, USADivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USAThe purpose of this study was to explore the relationships between heart rate variability (HRV) and various phenotypic measures that relate to health and functional status in chronic obstructive pulmonary disease (COPD), and secondly, to demonstrate the feasibility of ascertaining HRV via a chest-worn wearable biosensor in COPD patients. HRV analysis was performed using SDNN (standard deviation of the mean of all normal R-R intervals), low frequency (LF), high frequency (HF), and LF/HF ratio. We evaluated the associations between HRV and COPD severity, class of bronchodilator therapy prescribed, and patient reported outcomes. Seventy-nine participants with COPD were enrolled. There were no differences in SDNN, HF, and LF/HF ratio according to COPD severity. The SDNN in participants treated with concurrent beta-agonists and muscarinic antagonists was lower than that in other participants after adjusting heart rate (beta coefficient −3.980, <i>p</i> = 0.019). The SDNN was positively correlated with Veterans Specific Activity Questionnaire (VSAQ) score (<i>r</i> = 0.308, <i>p</i> = 0.006) and handgrip strength (<i>r</i> = 0.285, <i>p</i> = 0.011), and negatively correlated with dyspnea by modified Medical Research Council (mMRC) questionnaire (<i>r</i> = −0.234, <i>p</i> = 0.039), health status by Saint George’s Respiratory Questionnaire (SGRQ) (<i>r</i> = −0.298, <i>p</i> = 0.008), symptoms by COPD Assessment Test (CAT) (<i>r</i> = −0.280, <i>p</i> = 0.012), and BODE index (<i>r</i> = −0.269, <i>p</i> = 0.020). When measured by a chest-worn wearable device, reduced HRV was observed in COPD participants receiving inhaled beta-sympathomimetic agonist and muscarinic antagonists. HRV was also correlated with various health status and performance measures.https://www.mdpi.com/1424-8220/22/6/2264heart rate variabilitywearable sensorschronic obstructive pulmonary diseasebronchodilatorhealth |
| spellingShingle | Seon-Cheol Park Narongkorn Saiphoklang Donghyun Jung David Gomez Jonathan E. Phillips Brett A. Dolezal Donald P. Tashkin Igor Barjaktarevic Christopher B. Cooper Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease Severity Sensors heart rate variability wearable sensors chronic obstructive pulmonary disease bronchodilator health |
| title | Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease Severity |
| title_full | Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease Severity |
| title_fullStr | Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease Severity |
| title_full_unstemmed | Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease Severity |
| title_short | Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease Severity |
| title_sort | use of a wearable biosensor to study heart rate variability in chronic obstructive pulmonary disease and its relationship to disease severity |
| topic | heart rate variability wearable sensors chronic obstructive pulmonary disease bronchodilator health |
| url | https://www.mdpi.com/1424-8220/22/6/2264 |
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