Urothelial carcinoma; an overview of histology, molecular subtypes, and clinical implications based on the latest WHO classification
The incidence of urothelial carcinoma is increasing worldwide (including in Iran). Bladder cancer can be classified in various manners according to the standardized histomorphology set by the World Health Organization (WHO). Various genetic modifications occurring at the DNA level and the resulting...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Society of Diabetic Nephropathy Prevention
2023-09-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-12-e21482.pdf |
| _version_ | 1797676485390106624 |
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| author | Fateme Khalatbari Miremad Moafi-Madani Ali Amin |
| author_facet | Fateme Khalatbari Miremad Moafi-Madani Ali Amin |
| author_sort | Fateme Khalatbari |
| collection | DOAJ |
| description | The incidence of urothelial carcinoma is increasing worldwide (including in Iran). Bladder cancer can be classified in various manners according to the standardized histomorphology set by the World Health Organization (WHO). Various genetic modifications occurring at the DNA level and the resulting variations in RNA expression give rise to different subcategories that have important implications for diagnosis, prognosis, and treatment. The molecular basis of these morphologic variances is now better understood because of recent developments in molecular biology. With updates on the genetic and clinical characteristics, we highlight the histologic traits of the divergent differentiation and subtypes recognized by the most recent WHO classification (5th edition). Molecular subtypes of lower and upper tract cancer can be used to characterize their clinical behaviors and determine therapeutic responses to neoadjuvant chemotherapy. In this overview article, we also present a preliminary analysis of our ongoing data collection on molecular features of urothelial carcinoma. |
| first_indexed | 2024-03-11T22:28:49Z |
| format | Article |
| id | doaj.art-624f76b696954d0d9d3b8e8436098c26 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-03-11T22:28:49Z |
| publishDate | 2023-09-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-624f76b696954d0d9d3b8e8436098c262023-09-23T11:33:13ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192023-09-01124e21482e2148210.34172/jnp.2023.21482jnp-21482Urothelial carcinoma; an overview of histology, molecular subtypes, and clinical implications based on the latest WHO classificationFateme Khalatbari0Miremad Moafi-Madani1Ali Amin2Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USADepartment of Epidemiology, Brown University, Providence, Rhode Island, USADepartment of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USAThe incidence of urothelial carcinoma is increasing worldwide (including in Iran). Bladder cancer can be classified in various manners according to the standardized histomorphology set by the World Health Organization (WHO). Various genetic modifications occurring at the DNA level and the resulting variations in RNA expression give rise to different subcategories that have important implications for diagnosis, prognosis, and treatment. The molecular basis of these morphologic variances is now better understood because of recent developments in molecular biology. With updates on the genetic and clinical characteristics, we highlight the histologic traits of the divergent differentiation and subtypes recognized by the most recent WHO classification (5th edition). Molecular subtypes of lower and upper tract cancer can be used to characterize their clinical behaviors and determine therapeutic responses to neoadjuvant chemotherapy. In this overview article, we also present a preliminary analysis of our ongoing data collection on molecular features of urothelial carcinoma.https://nephropathol.com/PDF/jnp-12-e21482.pdfbladder cancerurothelial carcinomalower tract urothelial carcinomaupper tract urothelial carcinoma |
| spellingShingle | Fateme Khalatbari Miremad Moafi-Madani Ali Amin Urothelial carcinoma; an overview of histology, molecular subtypes, and clinical implications based on the latest WHO classification Journal of Nephropathology bladder cancer urothelial carcinoma lower tract urothelial carcinoma upper tract urothelial carcinoma |
| title | Urothelial carcinoma; an overview of histology, molecular subtypes, and clinical implications based on the latest WHO classification |
| title_full | Urothelial carcinoma; an overview of histology, molecular subtypes, and clinical implications based on the latest WHO classification |
| title_fullStr | Urothelial carcinoma; an overview of histology, molecular subtypes, and clinical implications based on the latest WHO classification |
| title_full_unstemmed | Urothelial carcinoma; an overview of histology, molecular subtypes, and clinical implications based on the latest WHO classification |
| title_short | Urothelial carcinoma; an overview of histology, molecular subtypes, and clinical implications based on the latest WHO classification |
| title_sort | urothelial carcinoma an overview of histology molecular subtypes and clinical implications based on the latest who classification |
| topic | bladder cancer urothelial carcinoma lower tract urothelial carcinoma upper tract urothelial carcinoma |
| url | https://nephropathol.com/PDF/jnp-12-e21482.pdf |
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