Systematic review on gene–sun exposure interactions in skin cancer
Abstract Background The risk of skin cancer is determined by environmental factors like ultraviolet radiation (UVR), personal habits like time spent outdoors and genetic factors. This review aimed to survey existing studies in gene–environment (GxE) interaction on skin cancer risk, and report on GxE...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Molecular Genetics & Genomic Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mgg3.2259 |
| _version_ | 1797661316081516544 |
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| author | Rasha Shraim Mohamed Ziad Farran George He Jelena Marunica Karsaj Lina Zgaga Ross McManus |
| author_facet | Rasha Shraim Mohamed Ziad Farran George He Jelena Marunica Karsaj Lina Zgaga Ross McManus |
| author_sort | Rasha Shraim |
| collection | DOAJ |
| description | Abstract Background The risk of skin cancer is determined by environmental factors like ultraviolet radiation (UVR), personal habits like time spent outdoors and genetic factors. This review aimed to survey existing studies in gene–environment (GxE) interaction on skin cancer risk, and report on GxE effect estimates. Methods We searched Embase, Medline (Ovid) and Web of Science (Core Collection) and included only primary research that reported on GxE on the risk of the three most common types of skin cancer: basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma. Quality assessment followed the Newcastle–Ottawa Scale. Meta‐analysis was not possible because no two studies examined the same interaction. This review was registered on PROSPERO (CRD42021238064). Results In total 260 records were identified after exclusion of duplicates. Fifteen studies were included in the final synthesis—12 used candidate gene approach. We found some evidence of GxE interactions with sun exposure, notably, with MC1R, CAT and NOS1 genes in melanoma, HAL and IL23A in BCC and HAL and XRCC1 in SCC. Conclusion Sun exposure seems to interact with genes involved in pigmentation, oxidative stress and immunosuppression, indicating that excessive UV exposure might exhaust oxidative defence and repair systems differentially, dependent on genetic make‐up. Further research is warranted to better understand skin cancer epidemiology and develop sun exposure recommendations. A genome‐wide approach is recommended as it might uncover unknown disease pathways dependent on UV radiation. |
| first_indexed | 2024-03-11T18:42:42Z |
| format | Article |
| id | doaj.art-625091c05bea40f7b9f0ecc14a083e14 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-03-11T18:42:42Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-625091c05bea40f7b9f0ecc14a083e142023-10-12T08:38:42ZengWileyMolecular Genetics & Genomic Medicine2324-92692023-10-011110n/an/a10.1002/mgg3.2259Systematic review on gene–sun exposure interactions in skin cancerRasha Shraim0Mohamed Ziad Farran1George He2Jelena Marunica Karsaj3Lina Zgaga4Ross McManus5Department of Public Health and Primary Care, Institute of Population Health Trinity College Dublin Dublin IrelandDepartment of Public Health and Primary Care, Institute of Population Health Trinity College Dublin Dublin IrelandDepartment of Public Health and Primary Care, Institute of Population Health Trinity College Dublin Dublin IrelandDepartment of Rheumatology, Physical Medicine and Rehabilitation Sestre milosrdnice University Hospital Center Zagreb CroatiaDepartment of Public Health and Primary Care, Institute of Population Health Trinity College Dublin Dublin IrelandDepartment of Clinical Medicine, Trinity Translational Medicine Institute Trinity College Dublin Dublin IrelandAbstract Background The risk of skin cancer is determined by environmental factors like ultraviolet radiation (UVR), personal habits like time spent outdoors and genetic factors. This review aimed to survey existing studies in gene–environment (GxE) interaction on skin cancer risk, and report on GxE effect estimates. Methods We searched Embase, Medline (Ovid) and Web of Science (Core Collection) and included only primary research that reported on GxE on the risk of the three most common types of skin cancer: basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma. Quality assessment followed the Newcastle–Ottawa Scale. Meta‐analysis was not possible because no two studies examined the same interaction. This review was registered on PROSPERO (CRD42021238064). Results In total 260 records were identified after exclusion of duplicates. Fifteen studies were included in the final synthesis—12 used candidate gene approach. We found some evidence of GxE interactions with sun exposure, notably, with MC1R, CAT and NOS1 genes in melanoma, HAL and IL23A in BCC and HAL and XRCC1 in SCC. Conclusion Sun exposure seems to interact with genes involved in pigmentation, oxidative stress and immunosuppression, indicating that excessive UV exposure might exhaust oxidative defence and repair systems differentially, dependent on genetic make‐up. Further research is warranted to better understand skin cancer epidemiology and develop sun exposure recommendations. A genome‐wide approach is recommended as it might uncover unknown disease pathways dependent on UV radiation.https://doi.org/10.1002/mgg3.2259BCCgene–environment interactionmelanomaSCCskin cancersun exposure |
| spellingShingle | Rasha Shraim Mohamed Ziad Farran George He Jelena Marunica Karsaj Lina Zgaga Ross McManus Systematic review on gene–sun exposure interactions in skin cancer Molecular Genetics & Genomic Medicine BCC gene–environment interaction melanoma SCC skin cancer sun exposure |
| title | Systematic review on gene–sun exposure interactions in skin cancer |
| title_full | Systematic review on gene–sun exposure interactions in skin cancer |
| title_fullStr | Systematic review on gene–sun exposure interactions in skin cancer |
| title_full_unstemmed | Systematic review on gene–sun exposure interactions in skin cancer |
| title_short | Systematic review on gene–sun exposure interactions in skin cancer |
| title_sort | systematic review on gene sun exposure interactions in skin cancer |
| topic | BCC gene–environment interaction melanoma SCC skin cancer sun exposure |
| url | https://doi.org/10.1002/mgg3.2259 |
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