Methylmercury Induces Mitochondria- and Endoplasmic Reticulum Stress-Dependent Pancreatic β-Cell Apoptosis via an Oxidative Stress-Mediated JNK Signaling Pathway

Methylmercury Induces Mitochondria- and Endoplasmic Reticulum Stress-Dependent Pancreatic β-Cell Apoptosis via an Oxidative Stress-Mediated JNK Signaling Pathway

Methylmercury (MeHg), a long-lasting organic pollutant, is known to induce cytotoxic effects in mammalian cells. Epidemiological studies have suggested that environmental exposure to MeHg is linked to the development of diabetes mellitus (DM). The exact molecular mechanism of MeHg-induced pancreatic...

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Bibliographic Details
Main Authors: Ching-Yao Yang, Shing-Hwa Liu, Chin-Chuan Su, Kai-Min Fang, Tsung-Yuan Yang, Jui-Ming Liu, Ya-Wen Chen, Kai-Chih Chang, Haw-Ling Chuang, Cheng-Tien Wu, Kuan-I Lee, Chun-Fa Huang
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
methylmercury
pancreatic β-cells
apoptosis
ER stress
c-Jun N-terminal kinase (JNK)
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/23/5/2858

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