Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area
This paper aims at retrospectively re-analyzing the different distribution, between males and females, in the allelic frequency of the human β T cell receptor (TCR β) single nucleotide polymorphism (SNPs) rs1800907 in Caucasian patients in the Milan metropolitan area. The allelic frequency significa...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/4/333 |
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| author | Elena M. Varoni Giovanni Lodi Massimo Del Fabbro Andrea Sardella Antonio Carrassi Marcello Iriti Pasquale Tripputi |
| author_facet | Elena M. Varoni Giovanni Lodi Massimo Del Fabbro Andrea Sardella Antonio Carrassi Marcello Iriti Pasquale Tripputi |
| author_sort | Elena M. Varoni |
| collection | DOAJ |
| description | This paper aims at retrospectively re-analyzing the different distribution, between males and females, in the allelic frequency of the human β T cell receptor (TCR β) single nucleotide polymorphism (SNPs) rs1800907 in Caucasian patients in the Milan metropolitan area. The allelic frequency significantly differed between sexes. Females showed higher frequency of C/C genotype than males, but lower T/C genotype (<i>p</i> < 0.0001). Heterozygous (T/C) versus homozygous (T/T + C/C) genotypes resulted in a different distribution of frequencies in males than in females, the latter possessing higher homozygosis (<i>p</i> < 0.0001). Within the limitations of this work (small number of included studies that concerned just a specific geographical area), allelic distribution according to sex might account the role of TCRβ-related SNPs in autoimmune diseases and further investigations are required to explain better this genetic background, in the perspective of a sex-related T cell immune responsiveness and auto-immunity. |
| first_indexed | 2024-03-10T12:42:33Z |
| format | Article |
| id | doaj.art-62521468054e4ff1ba8b1e97f6ba4d4c |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T12:42:33Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-62521468054e4ff1ba8b1e97f6ba4d4c2023-11-21T13:46:28ZengMDPI AGVaccines2076-393X2021-04-019433310.3390/vaccines9040333Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan AreaElena M. Varoni0Giovanni Lodi1Massimo Del Fabbro2Andrea Sardella3Antonio Carrassi4Marcello Iriti5Pasquale Tripputi6Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Via Beldiletto 1, 20142 Milano, ItalyDipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Via Beldiletto 1, 20142 Milano, ItalyDipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Via Beldiletto 1, 20142 Milano, ItalyDipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Via Beldiletto 1, 20142 Milano, ItalyDipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Via Beldiletto 1, 20142 Milano, ItalyNational Interuniveristy Consortium of Materials Science and Technology (INSTM), 50121 Firenze, ItalyDipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Via Beldiletto 1, 20142 Milano, ItalyThis paper aims at retrospectively re-analyzing the different distribution, between males and females, in the allelic frequency of the human β T cell receptor (TCR β) single nucleotide polymorphism (SNPs) rs1800907 in Caucasian patients in the Milan metropolitan area. The allelic frequency significantly differed between sexes. Females showed higher frequency of C/C genotype than males, but lower T/C genotype (<i>p</i> < 0.0001). Heterozygous (T/C) versus homozygous (T/T + C/C) genotypes resulted in a different distribution of frequencies in males than in females, the latter possessing higher homozygosis (<i>p</i> < 0.0001). Within the limitations of this work (small number of included studies that concerned just a specific geographical area), allelic distribution according to sex might account the role of TCRβ-related SNPs in autoimmune diseases and further investigations are required to explain better this genetic background, in the perspective of a sex-related T cell immune responsiveness and auto-immunity.https://www.mdpi.com/2076-393X/9/4/333genotype distributionpolymorphismheterozygosishomozygosis |
| spellingShingle | Elena M. Varoni Giovanni Lodi Massimo Del Fabbro Andrea Sardella Antonio Carrassi Marcello Iriti Pasquale Tripputi Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area Vaccines genotype distribution polymorphism heterozygosis homozygosis |
| title | Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area |
| title_full | Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area |
| title_fullStr | Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area |
| title_full_unstemmed | Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area |
| title_short | Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area |
| title_sort | sex related differences in allelic frequency of the human beta t cell receptor snp rs1800907 a retrospective analysis from milan metropolitan area |
| topic | genotype distribution polymorphism heterozygosis homozygosis |
| url | https://www.mdpi.com/2076-393X/9/4/333 |
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