Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 years and older

Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 years and older

Abstract Background Seasonal influenza causes significant morbidity and mortality with a disproportionately high disease burden in older adults. Strain-specific hemagglutination-inhibition (HAI) antibody titer is a well-established measure of humoral immunity against influenza and pre-vaccination HA...

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Main Authors: Bettina Wunderlich, Thomas Laskow, Huifen Li, Li Zhang, Engle Abrams, Jing Tian, Jun Yu, Yiyin Chen, Juliette Tavenier, Yushu Huang, Kawsar Talaat, Jay H. Bream, Qian-Li Xue, Graham Pawelec, Sean X. Leng
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Immunity & Ageing
Subjects:
Influenza vaccination
Older adults
HAI antibody titer
Interseason antibody waning
Pre-existing humoral immunity
Online Access:https://doi.org/10.1186/s12979-023-00362-8

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