Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A
Factor V (FV) Leiden and prothrombin G20210A are the most common hereditary thrombophilias. While their role in venous thromboembolism is well known, there are still uncertainties regarding their relationship with arterial thrombotic events, especially coronary ones. Our research, based on an in-dep...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/6/1371 |
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| author | Minerva Codruta Badescu Lăcrămioara Ionela Butnariu Alexandru Dan Costache Liliana Gheorghe Petronela Nicoleta Seritean Isac Adriana Chetran Sabina Andreea Leancă Irina Afrăsânie Ștefania-Teodora Duca Eusebiu Vlad Gorduza Irina Iuliana Costache Ciprian Rezus |
| author_facet | Minerva Codruta Badescu Lăcrămioara Ionela Butnariu Alexandru Dan Costache Liliana Gheorghe Petronela Nicoleta Seritean Isac Adriana Chetran Sabina Andreea Leancă Irina Afrăsânie Ștefania-Teodora Duca Eusebiu Vlad Gorduza Irina Iuliana Costache Ciprian Rezus |
| author_sort | Minerva Codruta Badescu |
| collection | DOAJ |
| description | Factor V (FV) Leiden and prothrombin G20210A are the most common hereditary thrombophilias. While their role in venous thromboembolism is well known, there are still uncertainties regarding their relationship with arterial thrombotic events, especially coronary ones. Our research, based on an in-depth analysis of the available literature, provides up-to-date information on the relationship between FV Leiden and prothrombin G20210A and acute myocardial infarction. FV Leiden and prothrombin G20210A screening should be implemented only in select cases, such as acute coronary syndrome in young individuals and/or in the absence of traditional cardiovascular risk factors and/or in the absence of significant coronary artery stenosis at angiography. Their identification should be followed by the implementation of optimal control of modifiable traditional cardiovascular risk factors to reduce the risk of recurrent events and genotyping and genetic counseling of all family members of affected cases for proper prophylaxis. An extended dual antiplatelet therapy (DAPT) may be considered, given the lower risk of bleeding under DAPT conferred by FV Leiden. |
| first_indexed | 2024-03-11T02:14:24Z |
| format | Article |
| id | doaj.art-6252ca4a589045fe9a820584c93c29a7 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T02:14:24Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-6252ca4a589045fe9a820584c93c29a72023-11-18T11:18:22ZengMDPI AGLife2075-17292023-06-01136137110.3390/life13061371Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210AMinerva Codruta Badescu0Lăcrămioara Ionela Butnariu1Alexandru Dan Costache2Liliana Gheorghe3Petronela Nicoleta Seritean Isac4Adriana Chetran5Sabina Andreea Leancă6Irina Afrăsânie7Ștefania-Teodora Duca8Eusebiu Vlad Gorduza9Irina Iuliana Costache10Ciprian Rezus11Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Radiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFactor V (FV) Leiden and prothrombin G20210A are the most common hereditary thrombophilias. While their role in venous thromboembolism is well known, there are still uncertainties regarding their relationship with arterial thrombotic events, especially coronary ones. Our research, based on an in-depth analysis of the available literature, provides up-to-date information on the relationship between FV Leiden and prothrombin G20210A and acute myocardial infarction. FV Leiden and prothrombin G20210A screening should be implemented only in select cases, such as acute coronary syndrome in young individuals and/or in the absence of traditional cardiovascular risk factors and/or in the absence of significant coronary artery stenosis at angiography. Their identification should be followed by the implementation of optimal control of modifiable traditional cardiovascular risk factors to reduce the risk of recurrent events and genotyping and genetic counseling of all family members of affected cases for proper prophylaxis. An extended dual antiplatelet therapy (DAPT) may be considered, given the lower risk of bleeding under DAPT conferred by FV Leiden.https://www.mdpi.com/2075-1729/13/6/1371myocardial infarctionfactor V Leidenprothrombin G20210Athrombophilia |
| spellingShingle | Minerva Codruta Badescu Lăcrămioara Ionela Butnariu Alexandru Dan Costache Liliana Gheorghe Petronela Nicoleta Seritean Isac Adriana Chetran Sabina Andreea Leancă Irina Afrăsânie Ștefania-Teodora Duca Eusebiu Vlad Gorduza Irina Iuliana Costache Ciprian Rezus Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A Life myocardial infarction factor V Leiden prothrombin G20210A thrombophilia |
| title | Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A |
| title_full | Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A |
| title_fullStr | Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A |
| title_full_unstemmed | Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A |
| title_short | Acute Myocardial Infarction in Patients with Hereditary Thrombophilia—A Focus on Factor V Leiden and Prothrombin G20210A |
| title_sort | acute myocardial infarction in patients with hereditary thrombophilia a focus on factor v leiden and prothrombin g20210a |
| topic | myocardial infarction factor V Leiden prothrombin G20210A thrombophilia |
| url | https://www.mdpi.com/2075-1729/13/6/1371 |
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