Recent progress in targeted delivery vectors based on biomimetic nanoparticles
Abstract Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs) since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological vectors including cell membranes, extracellular vesicles (EVs), and viruses are considered promising candidates...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-06-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-021-00631-2 |
| _version_ | 1829477925972344832 |
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| author | Li Chen Weiqi Hong Wenyan Ren Ting Xu Zhiyong Qian Zhiyao He |
| author_facet | Li Chen Weiqi Hong Wenyan Ren Ting Xu Zhiyong Qian Zhiyao He |
| author_sort | Li Chen |
| collection | DOAJ |
| description | Abstract Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs) since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological vectors including cell membranes, extracellular vesicles (EVs), and viruses are considered promising candidates for targeted delivery owing to their biocompatibility and biodegradability. BNPs, the integration of biological vectors and functional agents, are anticipated to load cargos or camouflage synthetic nanoparticles to achieve targeted delivery. Despite their excellent intrinsic properties, natural vectors are deliberately modified to endow multiple functions such as good permeability, improved loading capability, and high specificity. Through structural modification and transformation of the vectors, they are pervasively utilized as more effective vehicles that can deliver contrast agents, chemotherapy drugs, nucleic acids, and genes to target sites for refractory disease therapy. This review summarizes recent advances in targeted delivery vectors based on cell membranes, EVs, and viruses, highlighting the potential applications of BNPs in the fields of biomedical imaging and therapy industry, as well as discussing the possibility of clinical translation and exploitation trend of these BNPs. |
| first_indexed | 2024-12-14T17:04:59Z |
| format | Article |
| id | doaj.art-62559b8d0aa443aa91d819c2ed056213 |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-12-14T17:04:59Z |
| publishDate | 2021-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-62559b8d0aa443aa91d819c2ed0562132022-12-21T22:53:45ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352021-06-016112510.1038/s41392-021-00631-2Recent progress in targeted delivery vectors based on biomimetic nanoparticlesLi Chen0Weiqi Hong1Wenyan Ren2Ting Xu3Zhiyong Qian4Zhiyao He5Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityAbstract Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs) since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological vectors including cell membranes, extracellular vesicles (EVs), and viruses are considered promising candidates for targeted delivery owing to their biocompatibility and biodegradability. BNPs, the integration of biological vectors and functional agents, are anticipated to load cargos or camouflage synthetic nanoparticles to achieve targeted delivery. Despite their excellent intrinsic properties, natural vectors are deliberately modified to endow multiple functions such as good permeability, improved loading capability, and high specificity. Through structural modification and transformation of the vectors, they are pervasively utilized as more effective vehicles that can deliver contrast agents, chemotherapy drugs, nucleic acids, and genes to target sites for refractory disease therapy. This review summarizes recent advances in targeted delivery vectors based on cell membranes, EVs, and viruses, highlighting the potential applications of BNPs in the fields of biomedical imaging and therapy industry, as well as discussing the possibility of clinical translation and exploitation trend of these BNPs.https://doi.org/10.1038/s41392-021-00631-2 |
| spellingShingle | Li Chen Weiqi Hong Wenyan Ren Ting Xu Zhiyong Qian Zhiyao He Recent progress in targeted delivery vectors based on biomimetic nanoparticles Signal Transduction and Targeted Therapy |
| title | Recent progress in targeted delivery vectors based on biomimetic nanoparticles |
| title_full | Recent progress in targeted delivery vectors based on biomimetic nanoparticles |
| title_fullStr | Recent progress in targeted delivery vectors based on biomimetic nanoparticles |
| title_full_unstemmed | Recent progress in targeted delivery vectors based on biomimetic nanoparticles |
| title_short | Recent progress in targeted delivery vectors based on biomimetic nanoparticles |
| title_sort | recent progress in targeted delivery vectors based on biomimetic nanoparticles |
| url | https://doi.org/10.1038/s41392-021-00631-2 |
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