8-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting it in Kidney-Transplanted Patients in Noor Hospital in Isfahan, Iran
Background: Kidney transplantation is the preferred treatment for most patients with end-stage renal disease (ESRD) and therefore, kidney transplantation survival analysis is important. The aim of this study was to determine the cumulative survival rate of renal transplantation and the factors affec...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2017-10-01
|
| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/8558 |
| _version_ | 1797720907971559424 |
|---|---|
| author | Mohsen Askarishahi Shahrzad Shahidi Abdolamir Atapoor Roya Hemayati Sajedeh Zeynali |
| author_facet | Mohsen Askarishahi Shahrzad Shahidi Abdolamir Atapoor Roya Hemayati Sajedeh Zeynali |
| author_sort | Mohsen Askarishahi |
| collection | DOAJ |
| description | Background: Kidney transplantation is the preferred treatment for most patients with end-stage renal disease (ESRD) and therefore, kidney transplantation survival analysis is important. The aim of this study was to determine the cumulative survival rate of renal transplantation and the factors affecting it.
Methods: This was a historic cohort study including information of 381 patients with end-stage renal disease who underwent kidney transplantation surgery from December 2007 to March 2016 in Noor hospital, Isfahan, Iran. The Kaplan-Meier method, Log Rank test and Cox regression model were used for statistical analysis. Data analysis was carried out with R software, Version 3.1.0, at the significance level of P < 0.05.
Findings: According to Kaplan-Mayer method, 1-, 3-, 5- and 8-year survival rates of transplanted kidney were estimated as 98.7, 93.3, 86.9, and 83.9 percent, respectively. The results of Cox regression model indicated that the time duration of dialysis before transplantation (P < 0.05), and the level of creatinine at the time of discharge from hospital (P < 0.05) had significant relationship with survival of transplanted kidney.
Conclusion: The survival rate of the transplanted kidney calculated for this center was suitable in comparison with other transplant centers. The level of creatinine at the time of discharge from hospital and the time duration of dialysis prior to transplantation were the factors influencing survival of the graft. |
| first_indexed | 2024-03-12T09:27:18Z |
| format | Article |
| id | doaj.art-6255abcb228d4b44893d8e2095813446 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:27:18Z |
| publishDate | 2017-10-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-6255abcb228d4b44893d8e20958134462023-09-02T14:08:47ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2017-10-01354421022102926218-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting it in Kidney-Transplanted Patients in Noor Hospital in Isfahan, IranMohsen Askarishahi0Shahrzad Shahidi1Abdolamir Atapoor2Roya Hemayati3Sajedeh Zeynali4Assistant Professor, Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranProfessor, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Internal Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranMSc Student, Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranBackground: Kidney transplantation is the preferred treatment for most patients with end-stage renal disease (ESRD) and therefore, kidney transplantation survival analysis is important. The aim of this study was to determine the cumulative survival rate of renal transplantation and the factors affecting it. Methods: This was a historic cohort study including information of 381 patients with end-stage renal disease who underwent kidney transplantation surgery from December 2007 to March 2016 in Noor hospital, Isfahan, Iran. The Kaplan-Meier method, Log Rank test and Cox regression model were used for statistical analysis. Data analysis was carried out with R software, Version 3.1.0, at the significance level of P < 0.05. Findings: According to Kaplan-Mayer method, 1-, 3-, 5- and 8-year survival rates of transplanted kidney were estimated as 98.7, 93.3, 86.9, and 83.9 percent, respectively. The results of Cox regression model indicated that the time duration of dialysis before transplantation (P < 0.05), and the level of creatinine at the time of discharge from hospital (P < 0.05) had significant relationship with survival of transplanted kidney. Conclusion: The survival rate of the transplanted kidney calculated for this center was suitable in comparison with other transplant centers. The level of creatinine at the time of discharge from hospital and the time duration of dialysis prior to transplantation were the factors influencing survival of the graft.http://jims.mui.ac.ir/index.php/jims/article/view/8558Kidney transplantationTransplantationSurvivalEnd-stage renal diseaseRegression analysis |
| spellingShingle | Mohsen Askarishahi Shahrzad Shahidi Abdolamir Atapoor Roya Hemayati Sajedeh Zeynali 8-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting it in Kidney-Transplanted Patients in Noor Hospital in Isfahan, Iran مجله دانشکده پزشکی اصفهان Kidney transplantation Transplantation Survival End-stage renal disease Regression analysis |
| title | 8-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting it in Kidney-Transplanted Patients in Noor Hospital in Isfahan, Iran |
| title_full | 8-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting it in Kidney-Transplanted Patients in Noor Hospital in Isfahan, Iran |
| title_fullStr | 8-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting it in Kidney-Transplanted Patients in Noor Hospital in Isfahan, Iran |
| title_full_unstemmed | 8-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting it in Kidney-Transplanted Patients in Noor Hospital in Isfahan, Iran |
| title_short | 8-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting it in Kidney-Transplanted Patients in Noor Hospital in Isfahan, Iran |
| title_sort | 8 year survival analysis of kidney transplantation and determining the factors affecting it in kidney transplanted patients in noor hospital in isfahan iran |
| topic | Kidney transplantation Transplantation Survival End-stage renal disease Regression analysis |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/8558 |
| work_keys_str_mv | AT mohsenaskarishahi 8yearsurvivalanalysisofkidneytransplantationanddeterminingthefactorsaffectingitinkidneytransplantedpatientsinnoorhospitalinisfahaniran AT shahrzadshahidi 8yearsurvivalanalysisofkidneytransplantationanddeterminingthefactorsaffectingitinkidneytransplantedpatientsinnoorhospitalinisfahaniran AT abdolamiratapoor 8yearsurvivalanalysisofkidneytransplantationanddeterminingthefactorsaffectingitinkidneytransplantedpatientsinnoorhospitalinisfahaniran AT royahemayati 8yearsurvivalanalysisofkidneytransplantationanddeterminingthefactorsaffectingitinkidneytransplantedpatientsinnoorhospitalinisfahaniran AT sajedehzeynali 8yearsurvivalanalysisofkidneytransplantationanddeterminingthefactorsaffectingitinkidneytransplantedpatientsinnoorhospitalinisfahaniran |