Determination of Mitotane (DDD) and Principal Metabolite by a Simple HPLC-UV Method and Its Validation in Human Plasma Samples

Determination of Mitotane (DDD) and Principal Metabolite by a Simple HPLC-UV Method and Its Validation in Human Plasma Samples

Mitotane (DDD) is prescribed in adrenocortical renal carcinoma. Its principal metabolite, dichlorodiphenylethene (DDE), can accumulate in fat tissues and from a toxicological point of view, is probably more interesting than the other metabolite dichlorodiphenylacetate (DDA). Therapeutic Drug Monitor...

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Bibliographic Details
Main Authors: Giacomo Luci, Federico Cucchiara, Laura Ciofi, Francesca Mattioli, Marianna Lastella, Romano Danesi, Antonello Di Paolo
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Separations
Subjects:
mitotane
dichlorodiphenyl ethene
high-performance liquid chromatography
plasma
metabolite
Online Access:https://www.mdpi.com/2297-8739/8/5/63

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